Ensayo clínico fase I para evaluar la terapia con Gliricidia sepium en lesiones cutáneas de primates de la familia Cebidae
For some time, the application of not traditional therapeutic options has been increased, as is the use of plants to the ones are attributed medicinal properties. Among the vegetable species that nave awoke interest for its action in vitro against some of the agents that cause dermatological infecti...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | español |
| Publicado: |
2005
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| Materias: | |
| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaiart?codigo=4804721 |
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| Sumario: | For some time, the application of not traditional therapeutic options has been increased, as is the use of plants to the ones are attributed medicinal properties. Among the vegetable species that nave awoke interest for its action in vitro against some of the agents that cause dermatological infections is Gliricidia sepium; that is known popular/y with the name of ";Matarratón";. In order to evaluating the activity of G. sepium as topical treatment of cutaneous infections, we designed a trial utilizing a watery extract of the plant in monkeys of the Cebidae family . A clinical phase I trial was carried out in a group of 16 primates, of which ones were chosen 5 with cutaneous wounds: 3 Alouatta seniculus monkeys, a Cebus capucinus and a Cebus apella. The watery extract of the plant was applied during five weeks, two times a day, in the following way: to the monkeys of the kind Alouatta, that permit direct contact with the humans, we applied the substance with a cotton on the wounds; to the monkeys of the species capucinus, it was placed in a cement container so that they bathed with the product; finally, to the monkeys of the species apella, that are aggressive, the extract was sprinkled over them inside its cage. To each one of the animals a direct exam with KOH and a micological cultivation, was carried out at the beginning and at the end of the trial. To the extension of the cutaneous commitment we realized a monitoring through photographic images of the clinical wounds utilizing light of Wood and direct light. We described the wounds with alopecia and descamation in the five animals and the result/t of the cultivation. The four first animals achieved an, almost, complete disappearance of the cutaneous wounds, without secondary effects. The case number five died in the first week of therapy because of a multisistemic failure caused by previous electric burns. The micological results are unstable and do not relate to the clinical answer. During the monitoring that was carried out for 5 weeks, they were not observed fallens of their lesions. The knowledge of the micosis and its ethiological agents in animals is very scarce. We do not know the role that play The isolated agents in the monkey’s skin. It was evident the clinical improvement of the animals during the treat¬ment period and in the subsequent monitoring we do not observed fallens. We rebrand the fact that there was not observed signs of toxicity or adversed effects that contraindicate its use. To standarize a method of application [or the plant, to evaluate the results of the treatment with Gliricidia sepium and its security in so scarce number of animals. and to extrapolate them to human beings. is really com¬plicated. Nevertheless. We offer an inexpensively and sure therapeutic alternative to the populations of low economic resources in tropical zones. Were the matarratón is of easy acquisition. |
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