Estudio de los niveles plasmáticos de homocisteína, ácido fólico y vitamina B-12 en una población limeña de jóvenes adultos
Objective: To describe the distribution of plasma homocysteine, folic acid, B-12 vitaminconcentrations among students living in the city of Lima, Peru. Material and Methods: Transversalcohort study of 65 young adults between 18 and 30 year-old. The plasma homocysteineconcentration was determined by...
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| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | español |
| Publicado: |
2004
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| Materias: | |
| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8374157 |
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| Sumario: | Objective: To describe the distribution of plasma homocysteine, folic acid, B-12 vitaminconcentrations among students living in the city of Lima, Peru. Material and Methods: Transversalcohort study of 65 young adults between 18 and 30 year-old. The plasma homocysteineconcentration was determined by fluorescence polarization inmunoassay FPIA from AbbottLaboratories, folic acid by ionic capture and vitamin B-12 by enzimatic assay. Results: Thedistribution of homocysteine values ranged from 1,40 to 24,04 mmol /L; geometric meanhomocysteine 8,32±5,46, median 7,76 mmol/L. Homocysteine geometric means were significantlyhigher (p=0,005) in men (9,97±4,81 mmol/L) than in women (7,35±2,03 mmol/L). Plasmahomocysteine level was significantly correlated with folic acid plasma level (r=-0,329, p=0,007)but not with B-12 vitamin. However, plasma homocysteine level was correlated with body massindex (r=0,391; p=0,001). Conclusions: The distribution of homocysteine levels in our sampleis within the reference range already reported. However, there was a complete shift of thehomocysteine distribution curve towards lower values. Plasma folic acid levels may be adeterminant factor in the variation of homocysteine levels |
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