Inmunopatogénesis, ingesta de sodio/potasio y sistema calicreínas-cininas en hipertensión arterial. Una revisión
Hypertension represents one of the main factors that contribute to morbidity and mortality worldwide, because it is associated with cardiovascular diseases. Hypertension affects approximately 1.3 billion people worldwide, with a trend of increasing prevalence and incidence rates. Fewer than half of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8467563 |
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| Summary: | Hypertension represents one of the main factors that contribute to morbidity and mortality worldwide, because it is associated with cardiovascular diseases. Hypertension affects approximately 1.3 billion people worldwide, with a trend of increasing prevalence and incidence rates. Fewer than half of the people are aware of their condition, and many others are aware, but either is not treated, or is inadequately treated, even though the treatment reduces the morbidity and mortality burden. The main pathophysiological mechanisms include: high sodium and low potassium intake, which leads to activation of the innate and adaptive branches of the immune system, including autoimmune processes, dysfunction of the renin-angiotensin-aldosterone system, alteration of the kallikreins-kinins, raising blood pressure levels in sensitive salt patients. As a chronic inflammatory condition, hypertension can be temporarily treated with immunosuppressant, such as mycophenolate mofetil, among other drugs. Similarly, the NLRP3 inflammasome has been suggested as a therapeutic alternative in kidney disease, hypertension, atrial fibrillation, atherothrombosis, among others, and drugs such as the selective inhibitor of the NLRP3 inflammasome, designated as MCC950, could be used for treatment purposes in these diseases. The objective of this review is to highlight immunopathogenesis, sodium and potassium intake, kallikrein-kinin system in the development of high blood pressure. |
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