Modulación del inflamasoma por Leishmania
Antigen-presenting cells, such as macrophages and dendritic cells, trigger signaling pathways capable of generating a great variety of effector molecules that are essential for the regulation of the immune response. In the development of leishmaniasis, the Leishmania parasite disrupts diverse si...
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| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | español |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8795203 |
| Etiquetas: |
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| Sumario: | Antigen-presenting cells, such as macrophages and dendritic cells,
trigger signaling pathways capable of generating a great variety of
effector molecules that are essential for the regulation of the immune
response. In the development of leishmaniasis, the Leishmania
parasite disrupts diverse signaling pathways in order to manipulate
the host immune response with the aim of surviving and being able
to establish an infection. Many reports have pointed out that different
species of Leishmania alter such signaling pathways in a differential
manner. Therefore, the current contribution undertook a review of the
literature to analyze how distinct Leishmania species differentially
modulate the canonical and non-canonical pathway of activating the
inflammasome. Also examined was the role in leishmaniasis of IL-1β
and gene polymorphisms of its gene, as well as the way in which some
antileishmanial drugs modulate the inflammasome. The databases
utilized for the search were PubMed, Science Direct, and Clinical Key. |
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