The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line
Using herbs in the Arab world is becoming increasingly common. Hence, there is a potential for pharmacokinetic and pharmacodynamic herb-drug interactions. Cytochrome P450 (CYP) enzymes and efflux transporter such as P-glycoprotein (P-gp) are vulnerable to modulation by the multiple active constituen...
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2024
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| author | Zihlif, Malek Tanina, Neda Batah, Abdelkader Tawaha, Khaled Qudsi, Shahd Hasoun, Luai Alsayed, Ahmad R. |
| author_browse | Alsayed, Ahmad R. Batah, Abdelkader Hasoun, Luai Qudsi, Shahd Tanina, Neda Tawaha, Khaled Zihlif, Malek |
| author_facet | Zihlif, Malek Tanina, Neda Batah, Abdelkader Tawaha, Khaled Qudsi, Shahd Hasoun, Luai Alsayed, Ahmad R. |
| author_sort | Zihlif, Malek |
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| description | Using herbs in the Arab world is becoming increasingly common. Hence, there is a potential for pharmacokinetic and pharmacodynamic herb-drug interactions. Cytochrome P450 (CYP) enzymes and efflux transporter such as P-glycoprotein (P-gp) are vulnerable to modulation by the multiple active constituents of herbs. To examine the effects of some herbal plants on the gene expression of CYP1A1 metabolizing enzyme and P-glycoprotein. Invitro approach using human breast cancer cell line MCF7 and human colon adenocarcinoma Caco2 cell line were used to evaluate the effects of ten herbal plants Paronychia argentea lam.,Achillea bibersteni L., Teucrium polium L., Achillea santolina L., Arbutus andrachne L., Ruta graveolens L. Chrysanthemum coronarium L., Iles paraguariensis A.st., Catha edulis Forsk.,and Anthemis palastina Boiss on the mRNA expression of CYP1A1 and P-gp. The toxicities of these plants on the cell lines were evaluated with tetrazolium dye MTT test. Only Catha edulis had shown anti-proliferative activity against MCF7, but not against Caco2. Paronychia argentea, Ruta graveolens and Catha edulis on MCF7 and Paronychia argentea, Arbutus andrachne,Chrysanthenum coronarium and Anthemis palastina on Caco2 observed induction of CYP1A1 with dose dependant manner. Variation between induction and inhibition were noticed with plant effects on P-gp expression. Paronychiaargentea has shown dose dependant induction effect, Anthemis palastina induced P-gp at high concentrations, Whereas both Teucrium polium and Catha edulis inhibit P-gp at 100μg/ml. The overall results indicate a potential food-drug interaction, which definitely should be investigated further on animal and human kinetic models. |
| first_indexed | 2026-10-16T04:21:29Z |
| format | Article |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>dialnet-ART0001821663</identifier><datestamp>2026-01-20</datestamp><dc:title>The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line</dc:title><dc:creator>Zihlif, Malek</dc:creator><dc:creator>Tanina, Neda</dc:creator><dc:creator>Batah, Abdelkader</dc:creator><dc:creator>Tawaha, Khaled</dc:creator><dc:creator>Qudsi, Shahd</dc:creator><dc:creator>Hasoun, Luai</dc:creator><dc:creator>Alsayed, Ahmad R.</dc:creator><dc:subject>food–drug interaction</dc:subject><dc:subject>in-vitro</dc:subject><dc:subject>anti-proliferative effects</dc:subject><dc:subject>cytochrome P450</dc:subject><dc:subject>p-glycoprotein</dc:subject><dc:description>Using herbs in the Arab world is becoming increasingly common. Hence, there is a potential for pharmacokinetic and pharmacodynamic herb-drug interactions. Cytochrome P450 (CYP) enzymes and efflux transporter such as P-glycoprotein (P-gp) are vulnerable to modulation by the multiple active constituents of herbs. To examine the effects of some herbal plants on the gene expression of CYP1A1 metabolizing enzyme and P-glycoprotein. Invitro approach using human breast cancer cell line MCF7 and human colon adenocarcinoma Caco2 cell line were used to evaluate the effects of ten herbal plants Paronychia argentea lam.,Achillea bibersteni L., Teucrium polium L., Achillea santolina L., Arbutus andrachne L., Ruta graveolens L. Chrysanthemum coronarium L., Iles paraguariensis A.st., Catha edulis Forsk.,and Anthemis palastina Boiss on the mRNA expression of CYP1A1 and P-gp. The toxicities of these plants on the cell lines were evaluated with tetrazolium dye MTT test. Only Catha edulis had shown anti-proliferative activity against MCF7, but not against Caco2. Paronychia argentea, Ruta graveolens and Catha edulis on MCF7 and Paronychia argentea, Arbutus andrachne,Chrysanthenum coronarium and Anthemis palastina on Caco2 observed induction of CYP1A1 with dose dependant manner. Variation between induction and inhibition were noticed with plant effects on P-gp expression. Paronychiaargentea has shown dose dependant induction effect, Anthemis palastina induced P-gp at high concentrations, Whereas both Teucrium polium and Catha edulis inhibit P-gp at 100μg/ml. The overall results indicate a potential food-drug interaction, which definitely should be investigated further on animal and human kinetic models.</dc:description><dc:date>2024</dc:date><dc:type>text (article)</dc:type><dc:format>application/pdf</dc:format><dc:identifier>https://dialnet.unirioja.es/servlet/oaiart?codigo=10540797</dc:identifier><dc:identifier>(Revista) ISSN 1886-3655</dc:identifier><dc:source>Pharmacy Practice (Granada), ISSN 1886-3655, Vol. 22, Nº. 2, 2024 (Ejemplar dedicado a: Apr- Jun)</dc:source><dc:language>eng</dc:language><dc:rights>LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI</dc:rights></oai_dc:dc> |
| id | dialnet-ART0001821663 |
| institution | Dialnet |
| language | eng |
| last_indexed | 2026-10-16T04:21:29Z |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| record_format | oai_dc |
| spelling | dialnet-ART00018216632026-01-20The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell lineZihlif, MalekTanina, NedaBatah, AbdelkaderTawaha, KhaledQudsi, ShahdHasoun, LuaiAlsayed, Ahmad R.food–drug interactionin-vitroanti-proliferative effectscytochrome P450p-glycoproteinUsing herbs in the Arab world is becoming increasingly common. Hence, there is a potential for pharmacokinetic and pharmacodynamic herb-drug interactions. Cytochrome P450 (CYP) enzymes and efflux transporter such as P-glycoprotein (P-gp) are vulnerable to modulation by the multiple active constituents of herbs. To examine the effects of some herbal plants on the gene expression of CYP1A1 metabolizing enzyme and P-glycoprotein. Invitro approach using human breast cancer cell line MCF7 and human colon adenocarcinoma Caco2 cell line were used to evaluate the effects of ten herbal plants Paronychia argentea lam.,Achillea bibersteni L., Teucrium polium L., Achillea santolina L., Arbutus andrachne L., Ruta graveolens L. Chrysanthemum coronarium L., Iles paraguariensis A.st., Catha edulis Forsk.,and Anthemis palastina Boiss on the mRNA expression of CYP1A1 and P-gp. The toxicities of these plants on the cell lines were evaluated with tetrazolium dye MTT test. Only Catha edulis had shown anti-proliferative activity against MCF7, but not against Caco2. Paronychia argentea, Ruta graveolens and Catha edulis on MCF7 and Paronychia argentea, Arbutus andrachne,Chrysanthenum coronarium and Anthemis palastina on Caco2 observed induction of CYP1A1 with dose dependant manner. Variation between induction and inhibition were noticed with plant effects on P-gp expression. Paronychiaargentea has shown dose dependant induction effect, Anthemis palastina induced P-gp at high concentrations, Whereas both Teucrium polium and Catha edulis inhibit P-gp at 100μg/ml. The overall results indicate a potential food-drug interaction, which definitely should be investigated further on animal and human kinetic models.2024text (article)application/pdfhttps://dialnet.unirioja.es/servlet/oaiart?codigo=10540797(Revista) ISSN 1886-3655Pharmacy Practice (Granada), ISSN 1886-3655, Vol. 22, Nº. 2, 2024 (Ejemplar dedicado a: Apr- Jun)engLICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI |
| spellingShingle | food–drug interaction in-vitro anti-proliferative effects cytochrome P450 p-glycoprotein Zihlif, Malek Tanina, Neda Batah, Abdelkader Tawaha, Khaled Qudsi, Shahd Hasoun, Luai Alsayed, Ahmad R. The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title | The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title_full | The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title_fullStr | The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title_full_unstemmed | The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title_short | The medicinal plants effects on the gene expression of cytochrome P450 and P-glycoprotein in cultured colonand breast cancer cell line |
| title_sort | medicinal plants effects on the gene expression of cytochrome p450 and p glycoprotein in cultured colonand breast cancer cell line |
| topic | food–drug interaction in-vitro anti-proliferative effects cytochrome P450 p-glycoprotein |
| url | https://dialnet.unirioja.es/servlet/oaiart?codigo=10540797 |
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