Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia
<p id="p1">Stem cell therapies hold promise for enhancing infertility treatments through improved differentiation and cytokine secretion mechanisms, particularly autologous stem cells known for safety and compatibility. Collaboration and ongoing research are essential for clinical adoption. Addition...
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| Autores principales: | , , , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2023
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1139607 |
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| _version_ | 1879164838942343168 |
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| author | Atwa, Ahmed Elbehairi, Serag Eldin I. Bakry, Sayed Mehany, Ahmed B.M. Ashry, Mahmoud Askar, Hussam Alfaifi, Mohammad Y. |
| author_browse | Alfaifi, Mohammad Y. Ashry, Mahmoud Askar, Hussam Atwa, Ahmed Bakry, Sayed Elbehairi, Serag Eldin I. Mehany, Ahmed B.M. |
| author_facet | Atwa, Ahmed Elbehairi, Serag Eldin I. Bakry, Sayed Mehany, Ahmed B.M. Ashry, Mahmoud Askar, Hussam Alfaifi, Mohammad Y. |
| author_sort | Atwa, Ahmed |
| building | IntechOpen |
| collection | Acceso abierto |
| description | <p id="p1">Stem cell therapies hold promise for enhancing infertility treatments through improved differentiation and cytokine secretion mechanisms, particularly autologous stem cells known for safety and compatibility. Collaboration and ongoing research are essential for clinical adoption. Additionally, cell-based treatments offer potential solutions for non-obstructive azoospermia NOA, a condition characterized by absent sperm in ejaculate. Traditional therapies have limitations, prompting exploration of spermatogonial stem cells SSCs and induced pluripotent stem cells iPSCs. Animal studies demonstrate successful fertility restoration <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">via</italic></em> SSC transplantation, and progress has been made in characterizing human SSCs. However, challenges persist in expanding human SSCs and optimizing iPSC differentiation. Further research is necessary to overcome technical hurdles, ensure safety, and offer a novel NOA treatment option, ultimately restoring fertility.</p> |
| doi_str_mv | 10.5772/intechopen.1003644 |
| first_indexed | 2026-10-15T21:40:42Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-1139607</identifier><datestamp>2023-11-15</datestamp>
<dc:title>Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia</dc:title>
<dc:creator>Ahmed Atwa</dc:creator>
<dc:creator>Serag Eldin I. Elbehairi</dc:creator>
<dc:creator>Sayed Bakry</dc:creator>
<dc:creator>Ahmed B.M. Mehany</dc:creator>
<dc:creator>Mahmoud Ashry</dc:creator>
<dc:creator>Hussam Askar</dc:creator>
<dc:creator>Mohammad Y. Alfaifi</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description><p id="p1">Stem cell therapies hold promise for enhancing infertility treatments through improved differentiation and cytokine secretion mechanisms, particularly autologous stem cells known for safety and compatibility. Collaboration and ongoing research are essential for clinical adoption. Additionally, cell-based treatments offer potential solutions for non-obstructive azoospermia NOA, a condition characterized by absent sperm in ejaculate. Traditional therapies have limitations, prompting exploration of spermatogonial stem cells SSCs and induced pluripotent stem cells iPSCs. Animal studies demonstrate successful fertility restoration <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">via</italic></em> SSC transplantation, and progress has been made in characterizing human SSCs. However, challenges persist in expanding human SSCs and optimizing iPSC differentiation. Further research is necessary to overcome technical hurdles, ensure safety, and offer a novel NOA treatment option, ultimately restoring fertility.</p></dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2023-11-15</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/1139607</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.1003644</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83769-736-6</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/1002782 ; Recent Advances in Male Reproductive System</dc:source>
</oai_dc:dc> |
| id | intech-1139607 |
| institution | IntechOpen |
| isbn | 978-1-83769-736-6 |
| language | English |
| last_indexed | 2026-10-15T21:40:42Z |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-11396072023-11-15 Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia Ahmed Atwa Serag Eldin I. Elbehairi Sayed Bakry Ahmed B.M. Mehany Mahmoud Ashry Hussam Askar Mohammad Y. Alfaifi Health Sciences <p id="p1">Stem cell therapies hold promise for enhancing infertility treatments through improved differentiation and cytokine secretion mechanisms, particularly autologous stem cells known for safety and compatibility. Collaboration and ongoing research are essential for clinical adoption. Additionally, cell-based treatments offer potential solutions for non-obstructive azoospermia NOA, a condition characterized by absent sperm in ejaculate. Traditional therapies have limitations, prompting exploration of spermatogonial stem cells SSCs and induced pluripotent stem cells iPSCs. Animal studies demonstrate successful fertility restoration <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">via</italic></em> SSC transplantation, and progress has been made in characterizing human SSCs. However, challenges persist in expanding human SSCs and optimizing iPSC differentiation. Further research is necessary to overcome technical hurdles, ensure safety, and offer a novel NOA treatment option, ultimately restoring fertility.</p> IntechOpen 2023-11-15 Chapter, Part Of Book https://www.intechopen.com/chapters/1139607 doi:10.5772/intechopen.1003644 en ISBN:978-1-83769-736-6 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/1002782 ; Recent Advances in Male Reproductive System |
| spellingShingle | Health Sciences Atwa, Ahmed Elbehairi, Serag Eldin I. Bakry, Sayed Mehany, Ahmed B.M. Ashry, Mahmoud Askar, Hussam Alfaifi, Mohammad Y. Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title | Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title_full | Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title_fullStr | Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title_full_unstemmed | Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title_short | Current Progress on the Curative Effects of Cell-Based Therapy for Patients with Non-Obstructive Azoospermia |
| title_sort | current progress on the curative effects of cell based therapy for patients with non obstructive azoospermia |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/1139607 |
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