Interleukin 17 and Interferon-Gamma, Key Cytokines for Inflammation and Diagnosis in <i>Helicobacter pylori</i> and Gastric Malignancies
<p id="p1"><em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em> infection is characterized by an inflammatory infiltrate that might be an important antecedent of g...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1173113 |
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| Sumario: | <p id="p1"><em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em> infection is characterized by an inflammatory infiltrate that might be an important antecedent of gastric cancer. Interferon-gamma (IFN-γ) and interleukin (IL)-17 are key cytokines produced by gastric T cells in <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em>-infected patients with gastric malignancies. We studied the levels of serum IL-17A in subjects positive to <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em> infection and diagnosed with gastric intestinal metaplasia and dysplasia, as well as in patients with <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em> infection and non-atrophic gastritis, along with control subjects. Results showed that <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em> can cause inflammation in the stomach, specifically in cases of gastric intestinal metaplasia and dysplasia in infected patients, leading to a significant rise in IL-17A serum levels. Accordingly, we propose to consider measuring serum IL-17A for managing <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Helicobacter pylori</italic></em>-infected patients, and potentially for predicting the risk of developing gastric cancer.</p> |
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| ISBN: | 978-0-85466-446-7 |
| DOI: | 10.5772/intechopen.1005301 |