Breast Cancer Heterogeneity and Its Implication in Precision Therapy
<p id="p1">Breast cancer (BC) is the most common cancer among women worldwide, with a progressive increase in its incidence. It is the second leading cause of cancer-related death in women, with most cases due to metastatic disease and its heterogeneity. Tumor heterogeneity is associated with differ...
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| Autores principales: | , , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1197553 |
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| Sumario: | <p id="p1">Breast cancer (BC) is the most common cancer among women worldwide, with a progressive increase in its incidence. It is the second leading cause of cancer-related death in women, with most cases due to metastatic disease and its heterogeneity. Tumor heterogeneity is associated with differences in molecular characteristics, which regulate hormonal receptor expression, HER2 amplification, proliferation, metastatic potential, drug resistance, etc. Molecular heterogeneity in BC presents multiple clinical challenges to accurately characterize and treat the disease. BC heterogeneity represents a challenge in selecting the most appropriate therapy for each patient and predicting prognosis. In this review, we discuss the different types of heterogeneity in BC, including imaging features, histopathological and immunohistochemical characteristics, the mechanisms involved, some molecular tests that allow exploring heterogeneity, and new treatment options.</p> |
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| ISBN: | 978-0-85466-464-1 |
| DOI: | 10.5772/intechopen.1007503 |