Substance P (SP) in the Retina
<p id="p1">Substance P (SP), a neuropeptide predominantly expressed in neurons of the central nervous system (CNS), including the retina, functions as a neuromodulator, and neurotransmitter. It is particularly significant in the context of neurodegenerative diseases such as Parkinson’s disease...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1205950 |
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| Sumario: | <p id="p1">Substance P (SP), a neuropeptide predominantly expressed in neurons of the central nervous system (CNS), including the retina, functions as a neuromodulator, and neurotransmitter. It is particularly significant in the context of neurodegenerative diseases such as Parkinson’s disease (PD). Emerging evidence also highlights the critical role of SP in various retinal diseases, including vitreoretinopathy, retinal vein occlusion, retinal sympathetic inflammatory responses, and diabetic retinopathy. Understanding the distribution and function of SP in the retina is therefore essential for elucidating its roles in both normal physiology and pathological conditions. This review summarizes recent advancements in the study of SP and its receptor, with a focus on their distribution, physiological roles, and involvement in retinal pathologies.</p> |
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| ISBN: | 978-1-83634-140-6 |
| DOI: | 10.5772/intechopen.1008670 |