Gamma Delta T Cell: A Unique Member of the T Cell Family with a Significant Role in Cancer Immunotherapy
<p id="p1">Harnessing the potential of the immune system to treat cancers has been the goal of many scientific investigations and recent advancements in tumor immunology have allowed for cancer immunotherapy to become a reality. T lymphocytes that express the γδ TCR (γδ T cel...
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| Autores principales: | , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1207643 |
| Etiquetas: |
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| Sumario: | <p id="p1">Harnessing the potential of the immune system to treat cancers has been the goal of many scientific investigations and recent advancements in tumor immunology have allowed for cancer immunotherapy to become a reality. T lymphocytes that express the γδ TCR (γδ T cells) do not require antigen presentation by target cells. Instead, they recognize phospho-antigens that accumulate in tumors with increased activity of the mevalonate metabolic pathway. Additionally, the Natural Killer Group 2D (NKG2D) on γδ T cells recognizes stress-induced self-antigens widely expressed on cancer cells, such as the MHC Class I-like stress-associated molecules MIC-A and MIC-B or the UL-16 binding proteins ULBP-1, 2, and 3. This recognition can mediate direct cytotoxicity against tumor cells without prior antigen exposure or priming. Moreover, γδ T cells can be expanded when stimulated with IL-2 and Zoledronate. Collectively, these biological qualities of γδ T cells make them a promising option for cancer immunotherapy.</p> |
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| ISBN: | 978-0-85466-863-2 |
| DOI: | 10.5772/intechopen.1008801 |