Perspective Chapter: A New Era in Viral Research during the Pandemic – Can Organoids Serve as an Alternative to Animal Models?
<p id="p1">The pandemic era has underscored an urgent demand for more human-relevant and ethical models in viral research. Animal models have been the primary method for studying viral infection dynamics, immune responses, and potential treatments for decades. However, their limitations in accuratel...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1211513 |
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| Sumario: | <p id="p1">The pandemic era has underscored an urgent demand for more human-relevant and ethical models in viral research. Animal models have been the primary method for studying viral infection dynamics, immune responses, and potential treatments for decades. However, their limitations in accurately simulating human-specific responses raise critical questions about the effectiveness of these models in predicting human disease outcomes. Organoids—three-dimensional, stem cell-derived structures replicating human tissues’ architecture and functionality—present a groundbreaking alternative. This review examines the transformative potential of organoids to replace animal models in virology, particularly under pandemic conditions that require rapid, precise, and ethically sound approaches. With their ability to closely mimic human tissue environments, organoids enable more accurate analysis of virus-host interactions and more predictive drug screening. Beyond advancing scientific precision, organoids significantly reduce the ethical concerns and logistical challenges associated with animal testing. As the virology field pivots toward these innovative, human-centered models, organoids stand to redefine research approaches, promising a new era in viral research that can accelerate the development of effective treatments and preventive strategies in the face of future pandemics.</p> |
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| ISBN: | 978-0-85466-333-0 |
| DOI: | 10.5772/intechopen.1010327 |