Potential Probiotics for the Therapy of Metabolic Dysfunction-Associated Steatotic Liver Disease
<p id="p1">Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent metabolic disorder globally, has presented an urgent need for effective therapeutic agents. The complex pathogenesis of MASLD and the failure of numerous clinical trials targeting this disease have prompted the...
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| Autores principales: | , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1217839 |
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| Sumario: | <p id="p1">Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent metabolic disorder globally, has presented an urgent need for effective therapeutic agents. The complex pathogenesis of MASLD and the failure of numerous clinical trials targeting this disease have prompted the exploration of probiotic intervention as a novel therapeutic strategy. Emerging evidence underscores the pivotal role of the gut-liver axis in MASLD progression, particularly through dysregulation of gut microbiota composition, impaired intestinal barrier integrity, and aberrant bacterial metabolite signaling. Preclinical studies indicate that specific probiotic strains may ameliorate MASLD by restoring microbial homeostasis, fortifying gut barrier function, and attenuating hepatic inflammation via gut-liver crosstalk. Preliminary clinical trials further support the beneficial effects of probiotics in reducing hepatic steatosis and improving metabolic parameters. Future research should prioritize elucidating strain-specific mechanisms, optimizing probiotic formulations, and addressing challenges related to long-term efficacy, safety, and personalized therapeutic regimens. This review comprehensively evaluates current evidence on probiotic applications for MASLD treatment and highlights critical directions for advancing translational research in this field.</p> |
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| ISBN: | 978-1-83635-262-4 |
| DOI: | 10.5772/intechopen.1009922 |