Pharmacological and Biological Strategies as Regulators of Scarless Wound Healing and Regeneration of Skin
<p id="p1">Adult human skin typically repairs deep wounds by forming scar tissue, a process that often results in compromised function and aesthetics. In stark contrast, observations of human fetal skin <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xl...
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| Autores principales: | , , , , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1223922 |
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| Sumario: | <p id="p1">Adult human skin typically repairs deep wounds by forming scar tissue, a process that often results in compromised function and aesthetics. In stark contrast, observations of human fetal skin <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in utero</italic></em>, up to certain gestational stages, demonstrate a remarkable capacity for true tissue regeneration, characterized by rapid healing and the complete absence of scar formation. This chapter explore into the specific cellular factors and their interplay with the extracellular matrix (ECM) that orchestrate this exceptional regenerative process, including multiple individual growth factors (GFs) (EGF, TGF-β, PDGF, FGF, IGF) and other collagen metabolism/deposition factors and inhibitors. Furthermore, we will discuss the distinctions between these relatively traditional pharmacological approaches of the application of growth factors and cytokines and cutting-edge innovative biological medicines, particularly cellular therapies. Looking at specific cell sources and cell therapies, we will examine elements and formulations collectively for their role in remodeling and functional restoration of skin tissue, which is similar to that seen in fetal wound healing. This comparative analysis will highlight their respective roles and potential in achieving anti-fibrotic and anti-scar effects in human skin, drawing insights from the unparalleled example of fetal regeneration.</p> |
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| ISBN: | 978-1-83634-764-4 |
| DOI: | 10.5772/intechopen.1012960 |