Fertility Preservation in Hematological Malignancies: A Growing Imperative
<p id="p1">Advances in successful treatment for hematological malignancies have dramatically improved patient survival, making fertility preservation a growing imperative for individuals of reproductive age. This review outlines key aspects of oncofertility, focusing on the mechanisms of treatment-i...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2026
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1229632 |
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| Sumario: | <p id="p1">Advances in successful treatment for hematological malignancies have dramatically improved patient survival, making fertility preservation a growing imperative for individuals of reproductive age. This review outlines key aspects of oncofertility, focusing on the mechanisms of treatment-induced damage, critical risk factors, and established strategies for preserving fertility in this patient population. Chemotherapy and radiotherapy, as forms of cytotoxic therapy, are known to induce gonadotoxicity by primarily affecting rapidly dividing ovarian cells, which results in the paradoxical depletion of the primordial follicle reserve. The risk of premature ovarian insufficiency (POI) is multifactorial, with patient age at the time of treatment, the specific chemotherapy regimen (e.g., alkylating agents), and the need for hematopoietic stem cell transplantation (HSCT) being the most critical predictors. Oocyte or embryo cryopreservation following a short protocol controlled ovarian stimulation the gold standard as a fertility preservation method. While medical advances offer viable options, a significant gap in physician-patient communication regarding fertility risks persists. The effective collaboration between hemato-oncologists and reproductive specialists is paramount for successful fertility preservation and enables patients to make informed decisions about their future reproductive health.</p> |
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| ISBN: | 978-1-83634-983-9 |
| DOI: | 10.5772/intechopen.1013663 |