Estrogens in Liver Regeneration: From Molecular Mechanisms to Clinical Translation
<p>This chapter explores the role of estrogens in liver regeneration, emphasizing the molecular mechanisms and translational perspectives that connect basic science to potential clinical applications. The liver has a remarkable ability to regenerate after injury, and growing evidence highlights the...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2026
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1233271 |
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| Sumario: | <p>This chapter explores the role of estrogens in liver regeneration, emphasizing the molecular mechanisms and translational perspectives that connect basic science to potential clinical applications. The liver has a remarkable ability to regenerate after injury, and growing evidence highlights the key role that estrogens and their receptors play in this process. By modulating signaling pathways, gene expression, and cellular responses, estrogens influence the proliferation of hepatocytes, the resolution of inflammation, and the restoration of functional liver mass. Experimental models, ranging from partial hepatectomy to toxin-induced damage, have provided valuable insights into these mechanisms and their components. Furthermore, understanding how estrogens promote regeneration may help develop novel therapeutic strategies for the treatment of acute and chronic liver disorders. This chapter aims to provide a comprehensive view of the mechanisms through which estrogens contribute to liver repair and to discuss the potential implications of these findings for future clinical applications. Understanding estrogen-driven regenerative mechanisms may unlock novel therapeutic strategies to support liver repair and improve outcomes in hepatic disorders.</p> |
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| ISBN: | 978-1-80631-943-5 |
| DOI: | 10.5772/intechopen.1012571 |