Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology
<p>Redox biology offers valuable insights into the molecular mechanisms underlying environmental toxicity. Under physiological conditions, reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS, respectively) play essential roles in cellular signaling and homeostasis. However, when their produ...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2026
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| Acceso en línea: | https://www.intechopen.com/chapters/1237157 |
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| author | Oliveira, Jerusa Maria de Carnib, Bianca Leite Floresta, Luciana R. S. Souza, Emilly V. de Destro, Ana Luiza F. Freitas, Renata Maria Pereira de Amorim, Philipe Lima de Silva, Anielle Christine A. Silva, Daniela de Melo e |
| author_browse | Amorim, Philipe Lima de Carnib, Bianca Leite Destro, Ana Luiza F. Floresta, Luciana R. S. Freitas, Renata Maria Pereira de Oliveira, Jerusa Maria de Silva, Anielle Christine A. Silva, Daniela de Melo e Souza, Emilly V. de |
| author_facet | Oliveira, Jerusa Maria de Carnib, Bianca Leite Floresta, Luciana R. S. Souza, Emilly V. de Destro, Ana Luiza F. Freitas, Renata Maria Pereira de Amorim, Philipe Lima de Silva, Anielle Christine A. Silva, Daniela de Melo e |
| author_sort | Oliveira, Jerusa Maria de |
| building | IntechOpen |
| collection | Acceso abierto |
| description | <p>Redox biology offers valuable insights into the molecular mechanisms underlying environmental toxicity. Under physiological conditions, reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS, respectively) play essential roles in cellular signaling and homeostasis. However, when their production exceeds antioxidant defenses, oxidative distress ensues – an imbalance linked to inflammation, genotoxicity, and chronic diseases. Redox toxicology explores how pollutants – including metals, pesticides, hydrocarbons, microplastics, and nanomaterials – disrupt these pathways by modulating transcription factors such as NRF2 and nuclear factor kappa B (NFκB), thereby triggering inflammatory and epigenetic responses. In this context, redox biomarkers – both enzymatic and non-enzymatic – have emerged as sensitive tools for the early detection of sublethal toxic effects. These biomarkers have been successfully applied in a wide range of organisms, from invertebrates and corals to fish, amphibians, and mammals. Despite their promise, redox biomarkers may exhibit species-specific, organ-specific, and dose-dependent variability, requiring integrative approaches for robust interpretation. The increasing complexity of pollutant mixtures and interspecies variation in redox responses underscores the need for multiparametric and cross-disciplinary strategies. This chapter addresses the fundamentals of redox biology in ecotoxicology, explores the practical applications and limitations of redox biomarkers, and emphasizes the importance of integrated biomonitoring for accurate environmental risk assessment and biodiversity conservation.</p> |
| doi_str_mv | 10.5772/intechopen.1013761 |
| first_indexed | 2026-10-15T21:41:35Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-1237157</identifier><datestamp>2026-03-12</datestamp>
<dc:title>Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology</dc:title>
<dc:creator>Jerusa Maria de Oliveira</dc:creator>
<dc:creator>Bianca Leite Carnib</dc:creator>
<dc:creator>Luciana R. S.
Floresta</dc:creator>
<dc:creator>Emilly V. de Souza</dc:creator>
<dc:creator>Ana Luiza F. Destro</dc:creator>
<dc:creator>Renata
Maria Pereira de Freitas</dc:creator>
<dc:creator>Philipe Lima de Amorim</dc:creator>
<dc:creator>Anielle
Christine A. Silva</dc:creator>
<dc:creator>Daniela de Melo e Silva</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description><p>Redox biology offers valuable insights into the molecular mechanisms underlying environmental toxicity. Under physiological conditions, reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS, respectively) play essential roles in cellular signaling and homeostasis. However, when their production exceeds antioxidant defenses, oxidative distress ensues &ndash; an imbalance linked to inflammation, genotoxicity, and chronic diseases. Redox toxicology explores how pollutants &ndash; including metals, pesticides, hydrocarbons, microplastics, and nanomaterials &ndash; disrupt these pathways by modulating transcription factors such as NRF2 and nuclear factor kappa B (NF&kappa;B), thereby triggering inflammatory and epigenetic responses. In this context, redox biomarkers &ndash; both enzymatic and non-enzymatic &ndash; have emerged as sensitive tools for the early detection of sublethal toxic effects. These biomarkers have been successfully applied in a wide range of organisms, from invertebrates and corals to fish, amphibians, and mammals. Despite their promise, redox biomarkers may exhibit species-specific, organ-specific, and dose-dependent variability, requiring integrative approaches for robust interpretation. The increasing complexity of pollutant mixtures and interspecies variation in redox responses underscores the need for multiparametric and cross-disciplinary strategies. This chapter addresses the fundamentals of redox biology in ecotoxicology, explores the practical applications and limitations of redox biomarkers, and emphasizes the importance of integrated biomonitoring for accurate environmental risk assessment and biodiversity conservation.</p></dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2026-03-12</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/1237157</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.1013761</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-80631-082-1</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/1005034 ; Reactive Oxygen Species - An Overview</dc:source>
</oai_dc:dc> |
| id | intech-1237157 |
| institution | IntechOpen |
| isbn | 978-1-80631-082-1 |
| language | English |
| last_indexed | 2026-10-15T21:41:35Z |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-12371572026-03-12 Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology Jerusa Maria de Oliveira Bianca Leite Carnib Luciana R. S. Floresta Emilly V. de Souza Ana Luiza F. Destro Renata Maria Pereira de Freitas Philipe Lima de Amorim Anielle Christine A. Silva Daniela de Melo e Silva Life Sciences <p>Redox biology offers valuable insights into the molecular mechanisms underlying environmental toxicity. Under physiological conditions, reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS, respectively) play essential roles in cellular signaling and homeostasis. However, when their production exceeds antioxidant defenses, oxidative distress ensues – an imbalance linked to inflammation, genotoxicity, and chronic diseases. Redox toxicology explores how pollutants – including metals, pesticides, hydrocarbons, microplastics, and nanomaterials – disrupt these pathways by modulating transcription factors such as NRF2 and nuclear factor kappa B (NFκB), thereby triggering inflammatory and epigenetic responses. In this context, redox biomarkers – both enzymatic and non-enzymatic – have emerged as sensitive tools for the early detection of sublethal toxic effects. These biomarkers have been successfully applied in a wide range of organisms, from invertebrates and corals to fish, amphibians, and mammals. Despite their promise, redox biomarkers may exhibit species-specific, organ-specific, and dose-dependent variability, requiring integrative approaches for robust interpretation. The increasing complexity of pollutant mixtures and interspecies variation in redox responses underscores the need for multiparametric and cross-disciplinary strategies. This chapter addresses the fundamentals of redox biology in ecotoxicology, explores the practical applications and limitations of redox biomarkers, and emphasizes the importance of integrated biomonitoring for accurate environmental risk assessment and biodiversity conservation.</p> IntechOpen 2026-03-12 Chapter, Part Of Book https://www.intechopen.com/chapters/1237157 doi:10.5772/intechopen.1013761 en ISBN:978-1-80631-082-1 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/1005034 ; Reactive Oxygen Species - An Overview |
| spellingShingle | Life Sciences Oliveira, Jerusa Maria de Carnib, Bianca Leite Floresta, Luciana R. S. Souza, Emilly V. de Destro, Ana Luiza F. Freitas, Renata Maria Pereira de Amorim, Philipe Lima de Silva, Anielle Christine A. Silva, Daniela de Melo e Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title | Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title_full | Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title_fullStr | Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title_full_unstemmed | Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title_short | Biomarkers of Redox Biology as Tools for Assessing the Impact of Pollutants in Ecotoxicology |
| title_sort | biomarkers of redox biology as tools for assessing the impact of pollutants in ecotoxicology |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/1237157 |
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