Adenomyosis and Endometriosis: Two Faces of the Same Disease?
<p>Adenomyosis and endometriosis are chronic, estrogen-dependent gynecological disorders traditionally regarded as distinct entities but increasingly recognized as interrelated conditions within a shared disease spectrum. Both are characterized by the presence of ectopic endometrial tissue and are a...
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| Autores principales: | , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2026
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1240906 |
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| Sumario: | <p>Adenomyosis and endometriosis are chronic, estrogen-dependent gynecological disorders traditionally regarded as distinct entities but increasingly recognized as interrelated conditions within a shared disease spectrum. Both are characterized by the presence of ectopic endometrial tissue and are associated with chronic inflammation, immune dysregulation, altered hormonal signaling, and significant reproductive morbidity. This chapter explores the comparative etiopathogenesis of adenomyosis and endometriosis, highlighting common and divergent mechanisms, including junctional zone disruption, tissue injury and repair processes, stem and progenitor cell involvement, angiogenesis, neurogenesis, and genetic and epigenetic modulation. Emphasis is placed on mixed phenotypes, in which uterine and extrauterine disease coexist, creating diagnostic, staging, and therapeutic challenges. The chapter also reviews current concepts in clinical presentation, imaging-based diagnosis, and limitations of existing classification systems, underscoring the need for integrated, phenotype-oriented frameworks. Common and specific complications, including infertility, adverse obstetric outcomes, and surgical complexity, are critically discussed. Finally, contemporary management strategies are examined, contrasting conservative medical and surgical approaches with radical interventions, in line with recent international guidelines. Understanding adenomyosis and endometriosis as interconnected manifestations of a unified pathological continuum may improve diagnostic accuracy, individualized treatment planning, and reproductive outcomes.</p> |
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| ISBN: | 978-1-80631-484-3 |
| DOI: | 10.5772/intechopen.1014688 |