RNA Methylation and T Cells in Tumor Immunity: Functions, Therapeutic Strategies, and Prospections
<p>RNA methylation is an important post-transcriptional regulatory mechanism that influences gene expression in cancer and immune cells. Dysregulation of RNA methylation has been linked to tumor progression, immune evasion, and therapeutic resistance. In tumor immunity, immune cells function under c...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2026
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1248166 |
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| Sumario: | <p>RNA methylation is an important post-transcriptional regulatory mechanism that influences gene expression in cancer and immune cells. Dysregulation of RNA methylation has been linked to tumor progression, immune evasion, and therapeutic resistance. In tumor immunity, immune cells function under conditions of persistent antigen stimulation and immunosuppressive signaling, requiring dynamic regulation of RNA metabolism. This chapter summarizes major RNA methylation mechanisms and outlines their regulatory enzymes and immune-related functions. Particular emphasis is placed on the roles of RNA methylation in T cells across different functional stages, including development, activation, expansion, and exhaustion, and how these processes affect antitumor immune responses. These findings highlight RNA methylation as a regulatory layer influencing immunotherapy response and suggest that targeting RNA methylation may provide new strategies to overcome immunotherapy resistance.</p> |
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| ISBN: | 978-1-80632-051-6 |
| DOI: | 10.5772/intechopen.1015037 |