<em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach
The pineal hormone melatonin (MLT) is a derivative of the amino acid L-tryptophan and controls the circadian diurnal rhythm and the seasonal biorhythm. Exogenous administration is aimed at alleviating sleep-related dysfunctions and jet lag, as it decreases sleep-onset latency, increases total sleep...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2020
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| Acceso en línea: | https://www.intechopen.com/chapters/71070 |
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| _version_ | 1879164703652970496 |
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| author | Siamidi, Angeliki Dotsikas, Yannis |
| author_browse | Dotsikas, Yannis Siamidi, Angeliki |
| author_facet | Siamidi, Angeliki Dotsikas, Yannis |
| author_sort | Siamidi, Angeliki |
| building | IntechOpen |
| collection | Acceso abierto |
| description | The pineal hormone melatonin (MLT) is a derivative of the amino acid L-tryptophan and controls the circadian diurnal rhythm and the seasonal biorhythm. Exogenous administration is aimed at alleviating sleep-related dysfunctions and jet lag, as it decreases sleep-onset latency, increases total sleep time and improves overall sleep quality. Besides these indications, MLT has been shown to have other actions, such as antioxidant, immune enhancement and anticancer. It has also been shown to be useful against cardiovascular, neurological and psychiatric diseases. In the context of this work, a review of the related literature on the modified release of MLT from its per os administered formulations is presented, including the utilization of the design of experiments (DoE) for the selection of the optimal composition of melatonin formulations. The chapter offers an account of the recent advantages on MLT’s solid dosage forms suitable for treating sleep disorders, referring either to its onset or maintenance. |
| doi_str_mv | 10.5772/intechopen.91158 |
| first_indexed | 2026-10-15T21:38:33Z |
| format | Book Chapter |
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<dc:title><em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach</dc:title>
<dc:creator>Angeliki Siamidi</dc:creator>
<dc:creator>Yannis Dotsikas</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>The pineal hormone melatonin (MLT) is a derivative of the amino acid L-tryptophan and controls the circadian diurnal rhythm and the seasonal biorhythm. Exogenous administration is aimed at alleviating sleep-related dysfunctions and jet lag, as it decreases sleep-onset latency, increases total sleep time and improves overall sleep quality. Besides these indications, MLT has been shown to have other actions, such as antioxidant, immune enhancement and anticancer. It has also been shown to be useful against cardiovascular, neurological and psychiatric diseases. In the context of this work, a review of the related literature on the modified release of MLT from its per os administered formulations is presented, including the utilization of the design of experiments (DoE) for the selection of the optimal composition of melatonin formulations. The chapter offers an account of the recent advantages on MLT’s solid dosage forms suitable for treating sleep disorders, referring either to its onset or maintenance.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2020-02-12</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/71070</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.91158</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83962-908-2</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/8762 ; Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives</dc:source>
</oai_dc:dc> |
| id | intech-71070 |
| institution | IntechOpen |
| isbn | 978-1-83962-908-2 |
| language | English |
| last_indexed | 2026-10-15T21:38:33Z |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-710702020-02-12 <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach Angeliki Siamidi Yannis Dotsikas Health Sciences The pineal hormone melatonin (MLT) is a derivative of the amino acid L-tryptophan and controls the circadian diurnal rhythm and the seasonal biorhythm. Exogenous administration is aimed at alleviating sleep-related dysfunctions and jet lag, as it decreases sleep-onset latency, increases total sleep time and improves overall sleep quality. Besides these indications, MLT has been shown to have other actions, such as antioxidant, immune enhancement and anticancer. It has also been shown to be useful against cardiovascular, neurological and psychiatric diseases. In the context of this work, a review of the related literature on the modified release of MLT from its per os administered formulations is presented, including the utilization of the design of experiments (DoE) for the selection of the optimal composition of melatonin formulations. The chapter offers an account of the recent advantages on MLT’s solid dosage forms suitable for treating sleep disorders, referring either to its onset or maintenance. IntechOpen 2020-02-12 Chapter, Part Of Book https://www.intechopen.com/chapters/71070 doi:10.5772/intechopen.91158 en ISBN:978-1-83962-908-2 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/8762 ; Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives |
| spellingShingle | Health Sciences Siamidi, Angeliki Dotsikas, Yannis <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title | <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title_full | <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title_fullStr | <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title_full_unstemmed | <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title_short | <em>Per Os</em> Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach |
| title_sort | em per os em administered modified release solid formulations of melatonin a review of the latest developments including the design of experiments doe approach |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/71070 |
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