Primary Sclerosing Cholangitis (PSC) in Children
Primary sclerosing cholangitis (PSC) is a chronic liver disease of unknown aetiology affecting extrahepatic and/or intrahepatic bile ducts causing its inflammation and fibrosis with most frequent consequences including biliary cirrhosis and liver failure. The incidence of PSC in children and adolesc...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2020
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/71083 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1879164696945229824 |
|---|---|
| author | Wiecek, Sabina |
| author_browse | Wiecek, Sabina |
| author_facet | Wiecek, Sabina |
| author_sort | Wiecek, Sabina |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Primary sclerosing cholangitis (PSC) is a chronic liver disease of unknown aetiology affecting extrahepatic and/or intrahepatic bile ducts causing its inflammation and fibrosis with most frequent consequences including biliary cirrhosis and liver failure. The incidence of PSC in children and adolescents is 0.2 per 100,000 children per year, when in adults the reported incidence is higher and equals 0.5 to 1 in 100,000 individuals per year. PSC is more common among men and boys. The diagnosis is usually established in the second decade of life in the paediatric population with the mean age of diagnosis of 13.8 years. Many studies point out a strong correlation between IBD and PSC, especially ulcerative colitis. The prevalence of IBD among children with PSC diagnosis varies from 60 to 99%; however, the incidence of PSC is about 12% in patients with ulcerative colitis and fluctuates about 2–5% in Crohn’s disease diagnosed patients. Clinical symptoms are present in approximately half of cases and they are unspecific in many of them. Elevated liver enzymes and biochemical markers of cholestasis are sometimes the only signs of PSC. Gold standard for PSC diagnosis is magnetic resonance cholangiopancreatography (MRCP) as a non-invasive procedure comparing to endoscopic retrograde cholangiopancreatography (ERCP) which is also used in some cases. The aim of the study was to review the risk factors, clinical symptoms, diagnostic methods and treatment of paediatric patients with primary sclerosing cholangitis. |
| doi_str_mv | 10.5772/intechopen.90714 |
| first_indexed | 2026-10-15T21:38:27Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-71083</identifier><datestamp>2020-02-12</datestamp>
<dc:title>Primary Sclerosing Cholangitis (PSC) in Children</dc:title>
<dc:creator>Sabina Wiecek</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Primary sclerosing cholangitis (PSC) is a chronic liver disease of unknown aetiology affecting extrahepatic and/or intrahepatic bile ducts causing its inflammation and fibrosis with most frequent consequences including biliary cirrhosis and liver failure. The incidence of PSC in children and adolescents is 0.2 per 100,000 children per year, when in adults the reported incidence is higher and equals 0.5 to 1 in 100,000 individuals per year. PSC is more common among men and boys. The diagnosis is usually established in the second decade of life in the paediatric population with the mean age of diagnosis of 13.8 years. Many studies point out a strong correlation between IBD and PSC, especially ulcerative colitis. The prevalence of IBD among children with PSC diagnosis varies from 60 to 99%; however, the incidence of PSC is about 12% in patients with ulcerative colitis and fluctuates about 2–5% in Crohn’s disease diagnosed patients. Clinical symptoms are present in approximately half of cases and they are unspecific in many of them. Elevated liver enzymes and biochemical markers of cholestasis are sometimes the only signs of PSC. Gold standard for PSC diagnosis is magnetic resonance cholangiopancreatography (MRCP) as a non-invasive procedure comparing to endoscopic retrograde cholangiopancreatography (ERCP) which is also used in some cases. The aim of the study was to review the risk factors, clinical symptoms, diagnostic methods and treatment of paediatric patients with primary sclerosing cholangitis.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2020-02-12</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/71083</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.90714</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83880-672-9</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/7888 ; Hepatitis A and Other Associated Hepatobiliary Diseases</dc:source>
</oai_dc:dc> |
| id | intech-71083 |
| institution | IntechOpen |
| isbn | 978-1-83880-672-9 |
| language | English |
| last_indexed | 2026-10-15T21:38:27Z |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-710832020-02-12 Primary Sclerosing Cholangitis (PSC) in Children Sabina Wiecek Health Sciences Primary sclerosing cholangitis (PSC) is a chronic liver disease of unknown aetiology affecting extrahepatic and/or intrahepatic bile ducts causing its inflammation and fibrosis with most frequent consequences including biliary cirrhosis and liver failure. The incidence of PSC in children and adolescents is 0.2 per 100,000 children per year, when in adults the reported incidence is higher and equals 0.5 to 1 in 100,000 individuals per year. PSC is more common among men and boys. The diagnosis is usually established in the second decade of life in the paediatric population with the mean age of diagnosis of 13.8 years. Many studies point out a strong correlation between IBD and PSC, especially ulcerative colitis. The prevalence of IBD among children with PSC diagnosis varies from 60 to 99%; however, the incidence of PSC is about 12% in patients with ulcerative colitis and fluctuates about 2–5% in Crohn’s disease diagnosed patients. Clinical symptoms are present in approximately half of cases and they are unspecific in many of them. Elevated liver enzymes and biochemical markers of cholestasis are sometimes the only signs of PSC. Gold standard for PSC diagnosis is magnetic resonance cholangiopancreatography (MRCP) as a non-invasive procedure comparing to endoscopic retrograde cholangiopancreatography (ERCP) which is also used in some cases. The aim of the study was to review the risk factors, clinical symptoms, diagnostic methods and treatment of paediatric patients with primary sclerosing cholangitis. IntechOpen 2020-02-12 Chapter, Part Of Book https://www.intechopen.com/chapters/71083 doi:10.5772/intechopen.90714 en ISBN:978-1-83880-672-9 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/7888 ; Hepatitis A and Other Associated Hepatobiliary Diseases |
| spellingShingle | Health Sciences Wiecek, Sabina Primary Sclerosing Cholangitis (PSC) in Children |
| title | Primary Sclerosing Cholangitis (PSC) in Children |
| title_full | Primary Sclerosing Cholangitis (PSC) in Children |
| title_fullStr | Primary Sclerosing Cholangitis (PSC) in Children |
| title_full_unstemmed | Primary Sclerosing Cholangitis (PSC) in Children |
| title_short | Primary Sclerosing Cholangitis (PSC) in Children |
| title_sort | primary sclerosing cholangitis psc in children |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/71083 |
| work_keys_str_mv | AT wieceksabina primarysclerosingcholangitispscinchildren |