Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO)
A RCT conducted to assess the efficacy of letrozole as an ovulation induction agent in infertile women, and to compare the effectiveness of letrozole with the current standard agent, clomiphene citrate given for three successive cycles on the induction of ovulation. Forty-five infertile women with a...
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| Autores principales: | , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2020
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| Acceso en línea: | https://www.intechopen.com/chapters/71090 |
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| _version_ | 1879164709274386432 |
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| author | Abduljabbar, Hassan S.O. Hagras, Magda Magadmy, Rania |
| author_browse | Abduljabbar, Hassan S.O. Hagras, Magda Magadmy, Rania |
| author_facet | Abduljabbar, Hassan S.O. Hagras, Magda Magadmy, Rania |
| author_sort | Abduljabbar, Hassan S.O. |
| building | IntechOpen |
| collection | Acceso abierto |
| description | A RCT conducted to assess the efficacy of letrozole as an ovulation induction agent in infertile women, and to compare the effectiveness of letrozole with the current standard agent, clomiphene citrate given for three successive cycles on the induction of ovulation. Forty-five infertile women with anovulation included, the subjects were randomly divided into two groups; subjects were allocated to either CC (100) or letrozole (5 mg) daily—5 days starting on the third day of menses, for 3 months. On stimulation day 12 subjects, serum estradiol and transvaginal sonography to document the number of follicles was done. On stimulation day 21 subjects, serum progesterone and ultrasound for the thickness of endometrium was done. Participants were followed-up monthly. Results revealed that the mean number of follicles reaching >18 mm and endometrial thickness in the letrozole comparable to those receiving clomiphene citrate. Letrozole showed lower estradiol level compared to Clomiphene citrate (P < 0.05). Ovulation occurred in 84.4%, 78.1% in the letrozole and clomiphene citrate, respectively, and pregnancy rate is 18.8% in the letrozole group compared to 15% in the clomiphene citrate group. In conclusion, there was no significant increase in the number of follicles, endometrial thickness and pregnancy rate induced by letrozole compared with clomiphene citrate. |
| doi_str_mv | 10.5772/intechopen.90270 |
| first_indexed | 2026-10-15T21:38:38Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-71090</identifier><datestamp>2020-02-13</datestamp>
<dc:title>Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO)</dc:title>
<dc:creator>Hassan S.O. Abduljabbar</dc:creator>
<dc:creator>Magda Hagras</dc:creator>
<dc:creator>Rania Magadmy</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>A RCT conducted to assess the efficacy of letrozole as an ovulation induction agent in infertile women, and to compare the effectiveness of letrozole with the current standard agent, clomiphene citrate given for three successive cycles on the induction of ovulation. Forty-five infertile women with anovulation included, the subjects were randomly divided into two groups; subjects were allocated to either CC (100) or letrozole (5 mg) daily—5 days starting on the third day of menses, for 3 months. On stimulation day 12 subjects, serum estradiol and transvaginal sonography to document the number of follicles was done. On stimulation day 21 subjects, serum progesterone and ultrasound for the thickness of endometrium was done. Participants were followed-up monthly. Results revealed that the mean number of follicles reaching &gt;18 mm and endometrial thickness in the letrozole comparable to those receiving clomiphene citrate. Letrozole showed lower estradiol level compared to Clomiphene citrate (P &lt; 0.05). Ovulation occurred in 84.4%, 78.1% in the letrozole and clomiphene citrate, respectively, and pregnancy rate is 18.8% in the letrozole group compared to 15% in the clomiphene citrate group. In conclusion, there was no significant increase in the number of follicles, endometrial thickness and pregnancy rate induced by letrozole compared with clomiphene citrate.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2020-02-13</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/71090</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.90270</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83880-289-9</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/9165 ; Polycystic Ovarian Syndrome</dc:source>
</oai_dc:dc> |
| id | intech-71090 |
| institution | IntechOpen |
| isbn | 978-1-83880-289-9 |
| language | English |
| last_indexed | 2026-10-15T21:38:38Z |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-710902020-02-13 Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) Hassan S.O. Abduljabbar Magda Hagras Rania Magadmy Health Sciences A RCT conducted to assess the efficacy of letrozole as an ovulation induction agent in infertile women, and to compare the effectiveness of letrozole with the current standard agent, clomiphene citrate given for three successive cycles on the induction of ovulation. Forty-five infertile women with anovulation included, the subjects were randomly divided into two groups; subjects were allocated to either CC (100) or letrozole (5 mg) daily—5 days starting on the third day of menses, for 3 months. On stimulation day 12 subjects, serum estradiol and transvaginal sonography to document the number of follicles was done. On stimulation day 21 subjects, serum progesterone and ultrasound for the thickness of endometrium was done. Participants were followed-up monthly. Results revealed that the mean number of follicles reaching >18 mm and endometrial thickness in the letrozole comparable to those receiving clomiphene citrate. Letrozole showed lower estradiol level compared to Clomiphene citrate (P < 0.05). Ovulation occurred in 84.4%, 78.1% in the letrozole and clomiphene citrate, respectively, and pregnancy rate is 18.8% in the letrozole group compared to 15% in the clomiphene citrate group. In conclusion, there was no significant increase in the number of follicles, endometrial thickness and pregnancy rate induced by letrozole compared with clomiphene citrate. IntechOpen 2020-02-13 Chapter, Part Of Book https://www.intechopen.com/chapters/71090 doi:10.5772/intechopen.90270 en ISBN:978-1-83880-289-9 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/9165 ; Polycystic Ovarian Syndrome |
| spellingShingle | Health Sciences Abduljabbar, Hassan S.O. Hagras, Magda Magadmy, Rania Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title | Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title_full | Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title_fullStr | Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title_full_unstemmed | Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title_short | Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) |
| title_sort | effect of aromatase inhibitors versus clomiphene citrate for ovulation induction in infertile women with ovulatory dysfunction pco |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/71090 |
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