Radiation and DNA Methylation Mechanisms
There are two types of radiation, namely ionising and non-ionising radiation, the former of which interacts with atoms or molecules while the latter does not. Technological advances, evolving with the development of mankind, have led to gradually increasing exposure to radiation. Radiation-related i...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2020
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/72226 |
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| Sumario: | There are two types of radiation, namely ionising and non-ionising radiation, the former of which interacts with atoms or molecules while the latter does not. Technological advances, evolving with the development of mankind, have led to gradually increasing exposure to radiation. Radiation-related influences affect the cells that make up organisms in different ways, which means that they result in various effects in the affected organism. DNA methylation altered by radiation is one of the cellular systems affected in this context. DNA methylation is a major epigenetic mechanism that is particularly associated with cellular radiosensitivity, and it may also be associated with increased resistance to radiotherapy or chemotherapy. There is increasing scientific evidence that support this notion across a variety of study types from those that involve plants to those conducted with human subjects. Recent results with an increasing trend are available in this field. Our aim in this chapter is to describe the radiation environment and increasing exposure among humans as well as other living species, and to shed light on the effects of radiation on epigenetic mechanisms based on relevant scientific studies. |
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| ISBN: | 978-1-83880-817-4 |
| DOI: | 10.5772/intechopen.92189 |