New Tools for Studying Macrophage Polarization: Application to Bacterial Infections
Macrophages are tissue immune cells involved in homeostasis and are considered as the first line of defense during bacterial infections. They are resident cells but may be recruited during inflammation and/or infection. Hence, their study is necessary not only to decipher innate immune mechanisms in...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2020
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/72290 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Macrophages are tissue immune cells involved in homeostasis and are considered as the first line of defense during bacterial infections. They are resident cells but may be recruited during inflammation and/or infection. Hence, their study is necessary not only to decipher innate immune mechanisms involved in bacterial infections but also to follow infected patients. Among the numerous functions of macrophages, their polarization into microbicidal or permissive cells has been an interesting concept to describe their responses to bacterial aggression. Numerous in vitro studies, including ours, have shown the ability of bacteria to induce different patterns of macrophage polarization. However, the studies of patients during infections have produced less convincing results. We propose in this review to take stock of the tools for studying the polarization of macrophages and to show their limits. We make recommendations for using macrophage polarization as a biomarker for measuring severity and response to treatment in bacterial infectious diseases. |
|---|---|
| ISBN: | 978-1-78923-887-7 |
| DOI: | 10.5772/intechopen.92666 |