Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation
Pancreatic α-amylase binds to the N-glycan of glycoproteins. Here, I will show that pancreatic α-amylase has regulatory functions in the small intestine other than starch digestion. These new functions were revealed by identification of α-amylase-binding proteins in the intestinal brush border membr...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2020
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| Acceso en línea: | https://www.intechopen.com/chapters/72321 |
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| _version_ | 1879164696839323648 |
|---|---|
| author | Date, Kimie |
| author_browse | Date, Kimie |
| author_facet | Date, Kimie |
| author_sort | Date, Kimie |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Pancreatic α-amylase binds to the N-glycan of glycoproteins. Here, I will show that pancreatic α-amylase has regulatory functions in the small intestine other than starch digestion. These new functions were revealed by identification of α-amylase-binding proteins in the intestinal brush border membrane (BBM). This topic will include the following four parts: 1) identification of glycoproteins that bind pancreatic α-amylase in the small intestinal BBM; 2) interactions between pancreatic α-amylase and the binding glycoproteins, sucrose-isomaltase (α-glucosidase), and sodium/glucose co-transporter 1 (SGLT1), in which pancreatic α-amylase enhanced maltose degradation of sucrose-isomaltase under conditions including calcium and sodium, and inhibited glucose uptake of SGLT1; 3) localization of pancreatic α-amylase in the small intestine by binding to the BBM and being internalized into lysosomes through the endocytic pathway; and 4) expression of endogenous α-amylase in the duodenum: AMY2B, a pancreatic type α-amylase, is highly expressed in the human duodenum next to the pancreas. The α-amylase expression in the duodenum is required for proliferation and differentiation of human small intestinal epithelial cells. |
| doi_str_mv | 10.5772/intechopen.92660 |
| first_indexed | 2026-10-15T21:38:27Z |
| format | Book Chapter |
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<dc:title>Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation</dc:title>
<dc:creator>Kimie Date</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description>Pancreatic α-amylase binds to the N-glycan of glycoproteins. Here, I will show that pancreatic α-amylase has regulatory functions in the small intestine other than starch digestion. These new functions were revealed by identification of α-amylase-binding proteins in the intestinal brush border membrane (BBM). This topic will include the following four parts: 1) identification of glycoproteins that bind pancreatic α-amylase in the small intestinal BBM; 2) interactions between pancreatic α-amylase and the binding glycoproteins, sucrose-isomaltase (α-glucosidase), and sodium/glucose co-transporter 1 (SGLT1), in which pancreatic α-amylase enhanced maltose degradation of sucrose-isomaltase under conditions including calcium and sodium, and inhibited glucose uptake of SGLT1; 3) localization of pancreatic α-amylase in the small intestine by binding to the BBM and being internalized into lysosomes through the endocytic pathway; and 4) expression of endogenous α-amylase in the duodenum: AMY2B, a pancreatic type α-amylase, is highly expressed in the human duodenum next to the pancreas. The α-amylase expression in the duodenum is required for proliferation and differentiation of human small intestinal epithelial cells.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2020-05-28</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/72321</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.92660</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83968-455-5</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/7841 ; New Insights Into Metabolic Syndrome</dc:source>
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| id | intech-72321 |
| institution | IntechOpen |
| isbn | 978-1-83968-455-5 |
| language | English |
| last_indexed | 2026-10-15T21:38:27Z |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-723212020-05-28 Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation Kimie Date Life Sciences Pancreatic α-amylase binds to the N-glycan of glycoproteins. Here, I will show that pancreatic α-amylase has regulatory functions in the small intestine other than starch digestion. These new functions were revealed by identification of α-amylase-binding proteins in the intestinal brush border membrane (BBM). This topic will include the following four parts: 1) identification of glycoproteins that bind pancreatic α-amylase in the small intestinal BBM; 2) interactions between pancreatic α-amylase and the binding glycoproteins, sucrose-isomaltase (α-glucosidase), and sodium/glucose co-transporter 1 (SGLT1), in which pancreatic α-amylase enhanced maltose degradation of sucrose-isomaltase under conditions including calcium and sodium, and inhibited glucose uptake of SGLT1; 3) localization of pancreatic α-amylase in the small intestine by binding to the BBM and being internalized into lysosomes through the endocytic pathway; and 4) expression of endogenous α-amylase in the duodenum: AMY2B, a pancreatic type α-amylase, is highly expressed in the human duodenum next to the pancreas. The α-amylase expression in the duodenum is required for proliferation and differentiation of human small intestinal epithelial cells. IntechOpen 2020-05-28 Chapter, Part Of Book https://www.intechopen.com/chapters/72321 doi:10.5772/intechopen.92660 en ISBN:978-1-83968-455-5 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/7841 ; New Insights Into Metabolic Syndrome |
| spellingShingle | Life Sciences Date, Kimie Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title | Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title_full | Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title_fullStr | Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title_full_unstemmed | Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title_short | Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation |
| title_sort | regulatory functions of α amylase in the small intestine other than starch digestion α glucosidase activity glucose absorption cell proliferation and differentiation |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/72321 |
| work_keys_str_mv | AT datekimie regulatoryfunctionsofaamylaseinthesmallintestineotherthanstarchdigestionaglucosidaseactivityglucoseabsorptioncellproliferationanddifferentiation |