Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease
Glutathione (GSH) represents the major nonprotein thiol in cells and, alongside with glutathione-dependent enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST), exerts several biological functions including the protection against free radicals...
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| Autores principales: | , , , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2020
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/72621 |
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| _version_ | 1879164706578497536 |
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| author | Assmann, Charles Elias Stefanello, Naiara Bottari, Nathieli Bianchin Baldissarelli, Jucimara Schetinger, Maria Rosa Chitolina Morsch, Vera Maria Melchiors Bagatini, Margarete Dulce |
| author_browse | Assmann, Charles Elias Bagatini, Margarete Dulce Baldissarelli, Jucimara Bottari, Nathieli Bianchin Morsch, Vera Maria Melchiors Schetinger, Maria Rosa Chitolina Stefanello, Naiara |
| author_facet | Assmann, Charles Elias Stefanello, Naiara Bottari, Nathieli Bianchin Baldissarelli, Jucimara Schetinger, Maria Rosa Chitolina Morsch, Vera Maria Melchiors Bagatini, Margarete Dulce |
| author_sort | Assmann, Charles Elias |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Glutathione (GSH) represents the major nonprotein thiol in cells and, alongside with glutathione-dependent enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST), exerts several biological functions including the protection against free radicals and other essential metabolic reactions within the body. Disturbances in the homeostasis of this complex glutathione antioxidant system may damage cells and have been implicated with the development and progression of several human diseases. In this context, the immune and purinergic systems are also essential, since the dysregulation in both systems may also be correlated with numerous diseases. These two networks are closely related and control inflammatory responses, especially by the crosstalk of signaling molecules, receptors, and enzymes; thus, they can exacerbate or slow down the progression of diseases. Based on this background, we aimed to provide a general scenario of the purinergic and immune systems and the connection between both and the modulation of glutathione and glutathione-dependent enzyme expression and activity in the context of health and disease. |
| doi_str_mv | 10.5772/intechopen.92881 |
| first_indexed | 2026-10-15T21:38:36Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-72621</identifier><datestamp>2020-06-26</datestamp>
<dc:title>Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease</dc:title>
<dc:creator>Charles Elias Assmann</dc:creator>
<dc:creator>Naiara Stefanello</dc:creator>
<dc:creator>Nathieli Bianchin Bottari</dc:creator>
<dc:creator>Jucimara Baldissarelli</dc:creator>
<dc:creator>Maria Rosa Chitolina Schetinger</dc:creator>
<dc:creator>Vera Maria Melchiors Morsch</dc:creator>
<dc:creator>Margarete Dulce Bagatini</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Glutathione (GSH) represents the major nonprotein thiol in cells and, alongside with glutathione-dependent enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST), exerts several biological functions including the protection against free radicals and other essential metabolic reactions within the body. Disturbances in the homeostasis of this complex glutathione antioxidant system may damage cells and have been implicated with the development and progression of several human diseases. In this context, the immune and purinergic systems are also essential, since the dysregulation in both systems may also be correlated with numerous diseases. These two networks are closely related and control inflammatory responses, especially by the crosstalk of signaling molecules, receptors, and enzymes; thus, they can exacerbate or slow down the progression of diseases. Based on this background, we aimed to provide a general scenario of the purinergic and immune systems and the connection between both and the modulation of glutathione and glutathione-dependent enzyme expression and activity in the context of health and disease.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2020-06-26</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/72621</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.92881</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83880-125-0</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/9002 ; Glutathione System and Oxidative Stress in Health and Disease</dc:source>
</oai_dc:dc> |
| id | intech-72621 |
| institution | IntechOpen |
| isbn | 978-1-83880-125-0 |
| language | English |
| last_indexed | 2026-10-15T21:38:36Z |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-726212020-06-26 Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease Charles Elias Assmann Naiara Stefanello Nathieli Bianchin Bottari Jucimara Baldissarelli Maria Rosa Chitolina Schetinger Vera Maria Melchiors Morsch Margarete Dulce Bagatini Health Sciences Glutathione (GSH) represents the major nonprotein thiol in cells and, alongside with glutathione-dependent enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST), exerts several biological functions including the protection against free radicals and other essential metabolic reactions within the body. Disturbances in the homeostasis of this complex glutathione antioxidant system may damage cells and have been implicated with the development and progression of several human diseases. In this context, the immune and purinergic systems are also essential, since the dysregulation in both systems may also be correlated with numerous diseases. These two networks are closely related and control inflammatory responses, especially by the crosstalk of signaling molecules, receptors, and enzymes; thus, they can exacerbate or slow down the progression of diseases. Based on this background, we aimed to provide a general scenario of the purinergic and immune systems and the connection between both and the modulation of glutathione and glutathione-dependent enzyme expression and activity in the context of health and disease. IntechOpen 2020-06-26 Chapter, Part Of Book https://www.intechopen.com/chapters/72621 doi:10.5772/intechopen.92881 en ISBN:978-1-83880-125-0 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/9002 ; Glutathione System and Oxidative Stress in Health and Disease |
| spellingShingle | Health Sciences Assmann, Charles Elias Stefanello, Naiara Bottari, Nathieli Bianchin Baldissarelli, Jucimara Schetinger, Maria Rosa Chitolina Morsch, Vera Maria Melchiors Bagatini, Margarete Dulce Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title | Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title_full | Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title_fullStr | Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title_full_unstemmed | Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title_short | Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease |
| title_sort | crosstalk between the purinergic and immune systems implications for the glutathione antioxidant system in health and disease |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/72621 |
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