Pharmaceutical Applications of Vitamin E TPGS
D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2021
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| Acceso en línea: | https://www.intechopen.com/chapters/76413 |
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| _version_ | 1879164720309600256 |
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| author | Jasim, Adnan M. Jawad, Mohammed J. |
| author_browse | Jasim, Adnan M. Jawad, Mohammed J. |
| author_facet | Jasim, Adnan M. Jawad, Mohammed J. |
| author_sort | Jasim, Adnan M. |
| building | IntechOpen |
| collection | Acceso abierto |
| description | D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, vaccine system adjuvant, nutritional supplement, film plasticizer, anticancer reagent, and so on, are discussed in this review. Consequenly, TPGS can inhibit ATP-dependent P-glycoprotein activity and act as a potent excipient that promotes the efficiency of delivery and the therapeutic effect of drugs. Inhibition of P-gp occurs through mitochondria-dependent inhibition of the P-gp pump. Many of the latest studies address the use of TPGS for many poorly water-soluble or permeable drugs in the manufacture of nanodrugs or other formulations. In addition, it has been reported that TPGS shows a robust improvement in chylomicron secretion at low concentrations and improves intestinal lymphatic transport, which would also boost the potential of drug absorption. It also indicates that there are still many problems facing clinical translation of TPGS-based nanomedicines, requiring a more deep evaluation of TPGS properties and a future-based delivery method. |
| doi_str_mv | 10.5772/intechopen.97474 |
| first_indexed | 2026-10-15T21:38:49Z |
| format | Book Chapter |
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<dc:title>Pharmaceutical Applications of Vitamin E TPGS</dc:title>
<dc:creator>Adnan M. Jasim</dc:creator>
<dc:creator>Mohammed J. Jawad</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description>D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, vaccine system adjuvant, nutritional supplement, film plasticizer, anticancer reagent, and so on, are discussed in this review. Consequenly, TPGS can inhibit ATP-dependent P-glycoprotein activity and act as a potent excipient that promotes the efficiency of delivery and the therapeutic effect of drugs. Inhibition of P-gp occurs through mitochondria-dependent inhibition of the P-gp pump. Many of the latest studies address the use of TPGS for many poorly water-soluble or permeable drugs in the manufacture of nanodrugs or other formulations. In addition, it has been reported that TPGS shows a robust improvement in chylomicron secretion at low concentrations and improves intestinal lymphatic transport, which would also boost the potential of drug absorption. It also indicates that there are still many problems facing clinical translation of TPGS-based nanomedicines, requiring a more deep evaluation of TPGS properties and a future-based delivery method.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2021-08-30</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/76413</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.97474</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83968-837-9</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/9759 ; Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects</dc:source>
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| id | intech-76413 |
| institution | IntechOpen |
| isbn | 978-1-83968-837-9 |
| language | English |
| last_indexed | 2026-10-15T21:38:49Z |
| publishDate | 2021 |
| publishDateRange | 2021 |
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| spelling | intech-764132021-08-30 Pharmaceutical Applications of Vitamin E TPGS Adnan M. Jasim Mohammed J. Jawad Life Sciences D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, vaccine system adjuvant, nutritional supplement, film plasticizer, anticancer reagent, and so on, are discussed in this review. Consequenly, TPGS can inhibit ATP-dependent P-glycoprotein activity and act as a potent excipient that promotes the efficiency of delivery and the therapeutic effect of drugs. Inhibition of P-gp occurs through mitochondria-dependent inhibition of the P-gp pump. Many of the latest studies address the use of TPGS for many poorly water-soluble or permeable drugs in the manufacture of nanodrugs or other formulations. In addition, it has been reported that TPGS shows a robust improvement in chylomicron secretion at low concentrations and improves intestinal lymphatic transport, which would also boost the potential of drug absorption. It also indicates that there are still many problems facing clinical translation of TPGS-based nanomedicines, requiring a more deep evaluation of TPGS properties and a future-based delivery method. IntechOpen 2021-08-30 Chapter, Part Of Book https://www.intechopen.com/chapters/76413 doi:10.5772/intechopen.97474 en ISBN:978-1-83968-837-9 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/9759 ; Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects |
| spellingShingle | Life Sciences Jasim, Adnan M. Jawad, Mohammed J. Pharmaceutical Applications of Vitamin E TPGS |
| title | Pharmaceutical Applications of Vitamin E TPGS |
| title_full | Pharmaceutical Applications of Vitamin E TPGS |
| title_fullStr | Pharmaceutical Applications of Vitamin E TPGS |
| title_full_unstemmed | Pharmaceutical Applications of Vitamin E TPGS |
| title_short | Pharmaceutical Applications of Vitamin E TPGS |
| title_sort | pharmaceutical applications of vitamin e tpgs |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/76413 |
| work_keys_str_mv | AT jasimadnanm pharmaceuticalapplicationsofvitaminetpgs AT jawadmohammedj pharmaceuticalapplicationsofvitaminetpgs |