Time Series Analysis on the Conformational Change of c-Src Tyrosine Kinase
c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. We performed targeted molecular dynamics simulation to obtain trajectory of conformational change from inactive to active form. To investiga...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book Chapter |
| Language: | English |
| Published: |
IntechOpen
2021
|
| Subjects: | |
| Online Access: | https://www.intechopen.com/chapters/76732 |
| Tags: |
No Tags, Be the first to tag this record!
|
| Summary: | c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. We performed targeted molecular dynamics simulation to obtain trajectory of conformational change from inactive to active form. To investigate the conformational change of c-Src tyrosine kinase, we applied network analysis to time series of correlation among residues. The time series of correlation between residues during the conformational change generated by targeted molecular dynamic simulation. With centrality measures such as betweenness centrality, degree centrality, and closeness centrality, we observed a few important residues that significantly contribute to the conformational change of c-Src tyrosine kinase for the different time steps. |
|---|---|
| ISBN: | 978-1-83880-906-5 |
| DOI: | 10.5772/intechopen.97726 |