Pharmacogenetics and Tramadol-Related Fatalities
Tramadol (TR) is a widely prescribed pain killer because of its relatively safe profile among opioids. Nevertheless, intoxication can occur and overdose can lead to fatal outcomes. Surprisingly, in some fatalities for which death is attributable to TR alone, postmortem blood concentration levels ove...
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| Autores principales: | , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2021
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| Acceso en línea: | https://www.intechopen.com/chapters/77331 |
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| _version_ | 1879164746518757376 |
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| author | Aly, Sanaa M. Gaulier, Jean-Michel Allorge, Delphine |
| author_browse | Allorge, Delphine Aly, Sanaa M. Gaulier, Jean-Michel |
| author_facet | Aly, Sanaa M. Gaulier, Jean-Michel Allorge, Delphine |
| author_sort | Aly, Sanaa M. |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Tramadol (TR) is a widely prescribed pain killer because of its relatively safe profile among opioids. Nevertheless, intoxication can occur and overdose can lead to fatal outcomes. Surprisingly, in some fatalities for which death is attributable to TR alone, postmortem blood concentration levels overlap with the therapeutic concentration range. These fatal cases might be explained by pharmacokinetic and pharmacodynamic properties of TR that are known to be both enantioselective and influenced by genes. Indeed pharmacogenetics (PG) is of great importance in this issue as it has the ability to elucidate the genetic variation contributing to drug absorption, distribution, metabolism, excretion, and response so that adverse drug reactions, toxicity, and even death can be avoided. The aim of this chapter is to present this issue. |
| doi_str_mv | 10.5772/intechopen.98250 |
| first_indexed | 2026-10-15T21:39:14Z |
| format | Book Chapter |
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<dc:title>Pharmacogenetics and Tramadol-Related Fatalities</dc:title>
<dc:creator>Sanaa M. Aly</dc:creator>
<dc:creator>Jean-Michel Gaulier</dc:creator>
<dc:creator>Delphine Allorge</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Tramadol (TR) is a widely prescribed pain killer because of its relatively safe profile among opioids. Nevertheless, intoxication can occur and overdose can lead to fatal outcomes. Surprisingly, in some fatalities for which death is attributable to TR alone, postmortem blood concentration levels overlap with the therapeutic concentration range. These fatal cases might be explained by pharmacokinetic and pharmacodynamic properties of TR that are known to be both enantioselective and influenced by genes. Indeed pharmacogenetics (PG) is of great importance in this issue as it has the ability to elucidate the genetic variation contributing to drug absorption, distribution, metabolism, excretion, and response so that adverse drug reactions, toxicity, and even death can be avoided. The aim of this chapter is to present this issue.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2021-06-25</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/77331</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.98250</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83968-950-5</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/10579 ; Forensic Analysis - Scientific and Medical Techniques and Evidence under the Microscope</dc:source>
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| id | intech-77331 |
| institution | IntechOpen |
| isbn | 978-1-83968-950-5 |
| language | English |
| last_indexed | 2026-10-15T21:39:14Z |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-773312021-06-25 Pharmacogenetics and Tramadol-Related Fatalities Sanaa M. Aly Jean-Michel Gaulier Delphine Allorge Health Sciences Tramadol (TR) is a widely prescribed pain killer because of its relatively safe profile among opioids. Nevertheless, intoxication can occur and overdose can lead to fatal outcomes. Surprisingly, in some fatalities for which death is attributable to TR alone, postmortem blood concentration levels overlap with the therapeutic concentration range. These fatal cases might be explained by pharmacokinetic and pharmacodynamic properties of TR that are known to be both enantioselective and influenced by genes. Indeed pharmacogenetics (PG) is of great importance in this issue as it has the ability to elucidate the genetic variation contributing to drug absorption, distribution, metabolism, excretion, and response so that adverse drug reactions, toxicity, and even death can be avoided. The aim of this chapter is to present this issue. IntechOpen 2021-06-25 Chapter, Part Of Book https://www.intechopen.com/chapters/77331 doi:10.5772/intechopen.98250 en ISBN:978-1-83968-950-5 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10579 ; Forensic Analysis - Scientific and Medical Techniques and Evidence under the Microscope |
| spellingShingle | Health Sciences Aly, Sanaa M. Gaulier, Jean-Michel Allorge, Delphine Pharmacogenetics and Tramadol-Related Fatalities |
| title | Pharmacogenetics and Tramadol-Related Fatalities |
| title_full | Pharmacogenetics and Tramadol-Related Fatalities |
| title_fullStr | Pharmacogenetics and Tramadol-Related Fatalities |
| title_full_unstemmed | Pharmacogenetics and Tramadol-Related Fatalities |
| title_short | Pharmacogenetics and Tramadol-Related Fatalities |
| title_sort | pharmacogenetics and tramadol related fatalities |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/77331 |
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