Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment
Clinicians and researchers observing the natural history of endemic and epidemic infections have always been fascinated by the vagaries of these diseases, in terms of both the changing nature of the disease severity and phenotype over time and the variable susceptibility of hosts within exposed popu...
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| Autores principales: | , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2021
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| Acceso en línea: | https://www.intechopen.com/chapters/78433 |
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| _version_ | 1879164760790925312 |
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| author | Benlier, Necla Gundogdu, Nevhiz Ozkur, Mehtap |
| author_browse | Benlier, Necla Gundogdu, Nevhiz Ozkur, Mehtap |
| author_facet | Benlier, Necla Gundogdu, Nevhiz Ozkur, Mehtap |
| author_sort | Benlier, Necla |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Clinicians and researchers observing the natural history of endemic and epidemic infections have always been fascinated by the vagaries of these diseases, in terms of both the changing nature of the disease severity and phenotype over time and the variable susceptibility of hosts within exposed populations. SARS-CoV-2, the virus that causes COVID-19 and is believed to originate from bats, quickly transformed into a global pandemic. The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the global health in many aspects. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Comprehensive understanding of the biology of SARS-CoV-2 and its interaction with hosts is fundamentally important in the fight against SARS-CoV-2. Advanced age, male sex, and comorbidities such as hypertension and cardiovascular disease as well as diabetes and obesity have been identified as risk factors for more severe COVID-19. However, which and to what extent specific genetic factors may account for the predisposition of individuals to develop severe disease or to contract the infection remains elusive. The increasing availability of data from COVID-19 patient populations is allowing for potential associations to be established between specific gene loci and disease severity, susceptibility to infection, and response to current/future drugs. |
| doi_str_mv | 10.5772/intechopen.99877 |
| first_indexed | 2026-10-15T21:39:27Z |
| format | Book Chapter |
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<dc:title>Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment</dc:title>
<dc:creator>Necla Benlier</dc:creator>
<dc:creator>Nevhiz Gundogdu</dc:creator>
<dc:creator>Mehtap Ozkur</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description>Clinicians and researchers observing the natural history of endemic and epidemic infections have always been fascinated by the vagaries of these diseases, in terms of both the changing nature of the disease severity and phenotype over time and the variable susceptibility of hosts within exposed populations. SARS-CoV-2, the virus that causes COVID-19 and is believed to originate from bats, quickly transformed into a global pandemic. The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the global health in many aspects. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Comprehensive understanding of the biology of SARS-CoV-2 and its interaction with hosts is fundamentally important in the fight against SARS-CoV-2. Advanced age, male sex, and comorbidities such as hypertension and cardiovascular disease as well as diabetes and obesity have been identified as risk factors for more severe COVID-19. However, which and to what extent specific genetic factors may account for the predisposition of individuals to develop severe disease or to contract the infection remains elusive. The increasing availability of data from COVID-19 patient populations is allowing for potential associations to be established between specific gene loci and disease severity, susceptibility to infection, and response to current/future drugs.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2021-11-17</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/78433</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.99877</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83968-810-2</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/10886 ; Genetic Polymorphisms - New Insights</dc:source>
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| id | intech-78433 |
| institution | IntechOpen |
| isbn | 978-1-83968-810-2 |
| language | English |
| last_indexed | 2026-10-15T21:39:27Z |
| publishDate | 2021 |
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| publishDateSort | 2021 |
| publisher | IntechOpen |
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| spelling | intech-784332021-11-17 Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment Necla Benlier Nevhiz Gundogdu Mehtap Ozkur Life Sciences Clinicians and researchers observing the natural history of endemic and epidemic infections have always been fascinated by the vagaries of these diseases, in terms of both the changing nature of the disease severity and phenotype over time and the variable susceptibility of hosts within exposed populations. SARS-CoV-2, the virus that causes COVID-19 and is believed to originate from bats, quickly transformed into a global pandemic. The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the global health in many aspects. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Comprehensive understanding of the biology of SARS-CoV-2 and its interaction with hosts is fundamentally important in the fight against SARS-CoV-2. Advanced age, male sex, and comorbidities such as hypertension and cardiovascular disease as well as diabetes and obesity have been identified as risk factors for more severe COVID-19. However, which and to what extent specific genetic factors may account for the predisposition of individuals to develop severe disease or to contract the infection remains elusive. The increasing availability of data from COVID-19 patient populations is allowing for potential associations to be established between specific gene loci and disease severity, susceptibility to infection, and response to current/future drugs. IntechOpen 2021-11-17 Chapter, Part Of Book https://www.intechopen.com/chapters/78433 doi:10.5772/intechopen.99877 en ISBN:978-1-83968-810-2 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10886 ; Genetic Polymorphisms - New Insights |
| spellingShingle | Life Sciences Benlier, Necla Gundogdu, Nevhiz Ozkur, Mehtap Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title | Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title_full | Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title_fullStr | Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title_full_unstemmed | Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title_short | Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment |
| title_sort | human genetic polymorphisms associated with susceptibility to covid 19 infection and response to treatment |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/78433 |
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