New-Onset Refractory Status Epilepticus (NORSE)
<p id="p1">New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus without an obvious cause after initial investigations; “Initial” means 24 to 48 hours, to exclude stroke, other structural brain damage, drug overdoses and herpetic encephalitis. I...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2024
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| Acceso en línea: | https://www.intechopen.com/chapters/78521 |
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| _version_ | 1879164746676043776 |
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| author | Melykian, Gayane Ibrahim, Faisal Alarcon, Gonzalo Haddad, Naim Hail, Hassan Al Deleu, Dirk Sheikh, Lubna El Nofal, Yazan Mesraoua, Boulenouar |
| author_browse | Alarcon, Gonzalo Deleu, Dirk Haddad, Naim Hail, Hassan Al Ibrahim, Faisal Melykian, Gayane Mesraoua, Boulenouar Nofal, Yazan Sheikh, Lubna El |
| author_facet | Melykian, Gayane Ibrahim, Faisal Alarcon, Gonzalo Haddad, Naim Hail, Hassan Al Deleu, Dirk Sheikh, Lubna El Nofal, Yazan Mesraoua, Boulenouar |
| author_sort | Melykian, Gayane |
| building | IntechOpen |
| collection | Acceso abierto |
| description | <p id="p1">New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus without an obvious cause after initial investigations; “Initial” means 24 to 48 hours, to exclude stroke, other structural brain damage, drug overdoses and herpetic encephalitis. In the state of refractory status epilepticus (ES), patient suffers from repeated epileptic seizures without recovery of consciousness in between (Status epilepticus); these seizures do not respond to standard antiseizure medications (this refers to “refractory”). Recent studies suggest that these crises could be caused by an excess of pro-inflammatory molecules following a viral infection of the brain; however no evidence confirming this hypothesis has been demonstrated to date. Patients with NORSE are in the vast majority treated in intensive care units for several weeks or even months; despite the use of aggressive treatments such as therapeutic coma, and also immunotherapy, patients with NORSE face a high rate of complications and mortality; however a significant proportion of them eventually recover. NORSE survivors frequently suffer from epilepsy and cognitive impairment, a small minority eventually return to a normal lifestyle.</p> |
| doi_str_mv | 10.5772/intechopen.99004 |
| first_indexed | 2026-10-15T21:39:14Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-78521</identifier><datestamp>2024-11-20</datestamp>
<dc:title>New-Onset Refractory Status Epilepticus (NORSE)</dc:title>
<dc:creator>Gayane Melykian</dc:creator>
<dc:creator>Faisal Ibrahim</dc:creator>
<dc:creator>Gonzalo Alarcon</dc:creator>
<dc:creator>Naim Haddad</dc:creator>
<dc:creator>Hassan Al Hail</dc:creator>
<dc:creator>Dirk Deleu</dc:creator>
<dc:creator>Lubna El Sheikh</dc:creator>
<dc:creator>Yazan Nofal</dc:creator>
<dc:creator>Boulenouar Mesraoua</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description><p id="p1">New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus without an obvious cause after initial investigations; &ldquo;Initial&rdquo; means 24 to 48&nbsp;hours, to exclude stroke, other structural brain damage, drug overdoses and herpetic encephalitis. In the state of refractory status epilepticus (ES), patient suffers from repeated epileptic seizures without recovery of consciousness in between (Status epilepticus); these seizures do not respond to standard antiseizure medications (this refers to &ldquo;refractory&rdquo;). Recent studies suggest that these crises could be caused by an excess of pro-inflammatory molecules following a viral infection of the brain; however no evidence confirming this hypothesis has been demonstrated to date. Patients with NORSE are in the vast majority treated in intensive care units for several weeks or even months; despite the use of aggressive treatments such as therapeutic coma, and also immunotherapy, patients with NORSE face a high rate of complications and mortality; however a significant proportion of them eventually recover. NORSE survivors frequently suffer from epilepsy and cognitive impairment, a small minority eventually return to a normal lifestyle.</p></dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2024-11-20</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/78521</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.99004</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83968-985-7</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/10623 ; Status Epilepticus - Recent Advances in Epidemiology, Electroencephalography, Etiology, Diagnosis, and Treatment in Adults and Children</dc:source>
</oai_dc:dc> |
| id | intech-78521 |
| institution | IntechOpen |
| isbn | 978-1-83968-985-7 |
| language | English |
| last_indexed | 2026-10-15T21:39:14Z |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-785212024-11-20 New-Onset Refractory Status Epilepticus (NORSE) Gayane Melykian Faisal Ibrahim Gonzalo Alarcon Naim Haddad Hassan Al Hail Dirk Deleu Lubna El Sheikh Yazan Nofal Boulenouar Mesraoua Health Sciences <p id="p1">New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus without an obvious cause after initial investigations; “Initial” means 24 to 48 hours, to exclude stroke, other structural brain damage, drug overdoses and herpetic encephalitis. In the state of refractory status epilepticus (ES), patient suffers from repeated epileptic seizures without recovery of consciousness in between (Status epilepticus); these seizures do not respond to standard antiseizure medications (this refers to “refractory”). Recent studies suggest that these crises could be caused by an excess of pro-inflammatory molecules following a viral infection of the brain; however no evidence confirming this hypothesis has been demonstrated to date. Patients with NORSE are in the vast majority treated in intensive care units for several weeks or even months; despite the use of aggressive treatments such as therapeutic coma, and also immunotherapy, patients with NORSE face a high rate of complications and mortality; however a significant proportion of them eventually recover. NORSE survivors frequently suffer from epilepsy and cognitive impairment, a small minority eventually return to a normal lifestyle.</p> IntechOpen 2024-11-20 Chapter, Part Of Book https://www.intechopen.com/chapters/78521 doi:10.5772/intechopen.99004 en ISBN:978-1-83968-985-7 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10623 ; Status Epilepticus - Recent Advances in Epidemiology, Electroencephalography, Etiology, Diagnosis, and Treatment in Adults and Children |
| spellingShingle | Health Sciences Melykian, Gayane Ibrahim, Faisal Alarcon, Gonzalo Haddad, Naim Hail, Hassan Al Deleu, Dirk Sheikh, Lubna El Nofal, Yazan Mesraoua, Boulenouar New-Onset Refractory Status Epilepticus (NORSE) |
| title | New-Onset Refractory Status Epilepticus (NORSE) |
| title_full | New-Onset Refractory Status Epilepticus (NORSE) |
| title_fullStr | New-Onset Refractory Status Epilepticus (NORSE) |
| title_full_unstemmed | New-Onset Refractory Status Epilepticus (NORSE) |
| title_short | New-Onset Refractory Status Epilepticus (NORSE) |
| title_sort | new onset refractory status epilepticus norse |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/78521 |
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