Head Neck Squamous Cell Cancer Genomics: Oncogenes, Tumor Suppressor Genes and Clinical Implications
Head Neck Squamous Cell Cancer is genomically heterogenous. Common somatic mutations involve TP53, CDKN2A, FAT1, NOTCH1, PIK3CA, KMT2D and NSD1, less frequently others. Epigenetic changes also contribute to HNSCC biology. Alterations in tumor suppressor genes is a major oncogenic event in HNSCC. Gen...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2021
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/79142 |
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