Pulmonary Hypertension in Thalassemia Patients
Pulmonary hypertension (PH) is defined in children as a mean pulmonary arterial pressure (PAP) greater than 25 mmHg at rest or 30 mmHg during physical activity, with increased pulmonary artery capillary wedge pressure and an increased pulmonary vascular resistance greater than 3 Wood units × M2. it...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2021
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| Acceso en línea: | https://www.intechopen.com/chapters/79310 |
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| author | Alwataify, Ahmed Shemran Mutlaq Alfatlawy, Sabih Salih Altufaily, Yahia Abid Alshahid |
| author_browse | Alfatlawy, Sabih Salih Altufaily, Yahia Abid Alshahid Alwataify, Ahmed Shemran Mutlaq |
| author_facet | Alwataify, Ahmed Shemran Mutlaq Alfatlawy, Sabih Salih Altufaily, Yahia Abid Alshahid |
| author_sort | Alwataify, Ahmed Shemran Mutlaq |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Pulmonary hypertension (PH) is defined in children as a mean pulmonary arterial pressure (PAP) greater than 25 mmHg at rest or 30 mmHg during physical activity, with increased pulmonary artery capillary wedge pressure and an increased pulmonary vascular resistance greater than 3 Wood units × M2. it is the main cause of morbidity and mortality in the group of thalassemia, if no treatment leads to right ventricular heart failure and death. The development of pulmonary arterial hypertension (PAH) is assumed to be the result of many multifactorial pathogenic mechanisms including chronic hemolysis, iron overload, hypercoagulability, and erythrocyte dysfunction as a result of splenectomy, inflammation and nitric oxide (NO) depletion. PAH symptoms are non-specific, their signs consist of right ventricular lift, an accentuated pulmonary component of the second heart sound, a (gallop rhythm) right ventricular third heart sound, and parasternal heave meaning a hypertrophied right ventricle. The diagnosis of PAH requires a clinical suspicion based on symptoms and physical examination. Echocardiography is frequently used to screen for PAH, monitor progression over time and allow identification of patients for whom diagnostic right heart catheterization (RHC) is warranted and its treatment includes hemoglobinopathy specific treatment and PAH specific therapy. |
| doi_str_mv | 10.5772/intechopen.101052 |
| first_indexed | 2026-10-15T21:39:27Z |
| format | Book Chapter |
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<dc:title>Pulmonary Hypertension in Thalassemia Patients</dc:title>
<dc:creator>Ahmed Shemran Mutlaq Alwataify</dc:creator>
<dc:creator>Sabih Salih Alfatlawy</dc:creator>
<dc:creator>Yahia Abid Alshahid Altufaily</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Pulmonary hypertension (PH) is defined in children as a mean pulmonary arterial pressure (PAP) greater than 25 mmHg at rest or 30 mmHg during physical activity, with increased pulmonary artery capillary wedge pressure and an increased pulmonary vascular resistance greater than 3 Wood units × M2. it is the main cause of morbidity and mortality in the group of thalassemia, if no treatment leads to right ventricular heart failure and death. The development of pulmonary arterial hypertension (PAH) is assumed to be the result of many multifactorial pathogenic mechanisms including chronic hemolysis, iron overload, hypercoagulability, and erythrocyte dysfunction as a result of splenectomy, inflammation and nitric oxide (NO) depletion. PAH symptoms are non-specific, their signs consist of right ventricular lift, an accentuated pulmonary component of the second heart sound, a (gallop rhythm) right ventricular third heart sound, and parasternal heave meaning a hypertrophied right ventricle. The diagnosis of PAH requires a clinical suspicion based on symptoms and physical examination. Echocardiography is frequently used to screen for PAH, monitor progression over time and allow identification of patients for whom diagnostic right heart catheterization (RHC) is warranted and its treatment includes hemoglobinopathy specific treatment and PAH specific therapy.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2021-11-25</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/79310</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.101052</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83969-716-6</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/10876 ; Blood - Updates on Hemodynamics and on Thalassemia</dc:source>
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| id | intech-79310 |
| institution | IntechOpen |
| isbn | 978-1-83969-716-6 |
| language | English |
| last_indexed | 2026-10-15T21:39:27Z |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-793102021-11-25 Pulmonary Hypertension in Thalassemia Patients Ahmed Shemran Mutlaq Alwataify Sabih Salih Alfatlawy Yahia Abid Alshahid Altufaily Health Sciences Pulmonary hypertension (PH) is defined in children as a mean pulmonary arterial pressure (PAP) greater than 25 mmHg at rest or 30 mmHg during physical activity, with increased pulmonary artery capillary wedge pressure and an increased pulmonary vascular resistance greater than 3 Wood units × M2. it is the main cause of morbidity and mortality in the group of thalassemia, if no treatment leads to right ventricular heart failure and death. The development of pulmonary arterial hypertension (PAH) is assumed to be the result of many multifactorial pathogenic mechanisms including chronic hemolysis, iron overload, hypercoagulability, and erythrocyte dysfunction as a result of splenectomy, inflammation and nitric oxide (NO) depletion. PAH symptoms are non-specific, their signs consist of right ventricular lift, an accentuated pulmonary component of the second heart sound, a (gallop rhythm) right ventricular third heart sound, and parasternal heave meaning a hypertrophied right ventricle. The diagnosis of PAH requires a clinical suspicion based on symptoms and physical examination. Echocardiography is frequently used to screen for PAH, monitor progression over time and allow identification of patients for whom diagnostic right heart catheterization (RHC) is warranted and its treatment includes hemoglobinopathy specific treatment and PAH specific therapy. IntechOpen 2021-11-25 Chapter, Part Of Book https://www.intechopen.com/chapters/79310 doi:10.5772/intechopen.101052 en ISBN:978-1-83969-716-6 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10876 ; Blood - Updates on Hemodynamics and on Thalassemia |
| spellingShingle | Health Sciences Alwataify, Ahmed Shemran Mutlaq Alfatlawy, Sabih Salih Altufaily, Yahia Abid Alshahid Pulmonary Hypertension in Thalassemia Patients |
| title | Pulmonary Hypertension in Thalassemia Patients |
| title_full | Pulmonary Hypertension in Thalassemia Patients |
| title_fullStr | Pulmonary Hypertension in Thalassemia Patients |
| title_full_unstemmed | Pulmonary Hypertension in Thalassemia Patients |
| title_short | Pulmonary Hypertension in Thalassemia Patients |
| title_sort | pulmonary hypertension in thalassemia patients |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/79310 |
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