Tau in Health and Neurodegenerative Diseases
Tau, one of the major microtubule-associated proteins, modulates the dynamic properties of microtubules in the mammalian nervous system. Tau is abundantly expressed in the brain, particularly in the hippocampus. Insoluble and filamentous inclusions of tau in neurons or glia are discovered in neurode...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2021
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| Acceso en línea: | https://www.intechopen.com/chapters/79430 |
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| _version_ | 1879164768093208576 |
|---|---|
| author | Chu, Dandan Liu, Fei |
| author_browse | Chu, Dandan Liu, Fei |
| author_facet | Chu, Dandan Liu, Fei |
| author_sort | Chu, Dandan |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Tau, one of the major microtubule-associated proteins, modulates the dynamic properties of microtubules in the mammalian nervous system. Tau is abundantly expressed in the brain, particularly in the hippocampus. Insoluble and filamentous inclusions of tau in neurons or glia are discovered in neurodegenerative diseases termed ‘tauopathies’, including Alzheimer’s disease (AD), argyrophilic grain disease (AGD), corticobasal degeneration (CBD), frontotemporal dementia (FTD), Pick’s disease (PiD) and progressive supranuclear palsy (PSP). Accumulation of intracellular neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau, is directly correlated with the degree of Alzheimer's dementia. This chapter reviews the role of tau protein in physiological conditions and the pathological changes of tau related to neurodegenerative diseases. The applications of tau as a therapeutic target are also discussed. |
| doi_str_mv | 10.5772/intechopen.101299 |
| first_indexed | 2026-10-15T21:39:34Z |
| format | Book Chapter |
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<dc:title>Tau in Health and Neurodegenerative Diseases</dc:title>
<dc:creator>Dandan Chu</dc:creator>
<dc:creator>Fei Liu</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Tau, one of the major microtubule-associated proteins, modulates the dynamic properties of microtubules in the mammalian nervous system. Tau is abundantly expressed in the brain, particularly in the hippocampus. Insoluble and filamentous inclusions of tau in neurons or glia are discovered in neurodegenerative diseases termed ‘tauopathies’, including Alzheimer’s disease (AD), argyrophilic grain disease (AGD), corticobasal degeneration (CBD), frontotemporal dementia (FTD), Pick’s disease (PiD) and progressive supranuclear palsy (PSP). Accumulation of intracellular neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau, is directly correlated with the degree of Alzheimer's dementia. This chapter reviews the role of tau protein in physiological conditions and the pathological changes of tau related to neurodegenerative diseases. The applications of tau as a therapeutic target are also discussed.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2021-11-24</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/79430</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.101299</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83969-911-5</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/11019 ; Hippocampus - Cytoarchitecture and Diseases</dc:source>
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| id | intech-79430 |
| institution | IntechOpen |
| isbn | 978-1-83969-911-5 |
| language | English |
| last_indexed | 2026-10-15T21:39:34Z |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-794302021-11-24 Tau in Health and Neurodegenerative Diseases Dandan Chu Fei Liu Health Sciences Tau, one of the major microtubule-associated proteins, modulates the dynamic properties of microtubules in the mammalian nervous system. Tau is abundantly expressed in the brain, particularly in the hippocampus. Insoluble and filamentous inclusions of tau in neurons or glia are discovered in neurodegenerative diseases termed ‘tauopathies’, including Alzheimer’s disease (AD), argyrophilic grain disease (AGD), corticobasal degeneration (CBD), frontotemporal dementia (FTD), Pick’s disease (PiD) and progressive supranuclear palsy (PSP). Accumulation of intracellular neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau, is directly correlated with the degree of Alzheimer's dementia. This chapter reviews the role of tau protein in physiological conditions and the pathological changes of tau related to neurodegenerative diseases. The applications of tau as a therapeutic target are also discussed. IntechOpen 2021-11-24 Chapter, Part Of Book https://www.intechopen.com/chapters/79430 doi:10.5772/intechopen.101299 en ISBN:978-1-83969-911-5 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/11019 ; Hippocampus - Cytoarchitecture and Diseases |
| spellingShingle | Health Sciences Chu, Dandan Liu, Fei Tau in Health and Neurodegenerative Diseases |
| title | Tau in Health and Neurodegenerative Diseases |
| title_full | Tau in Health and Neurodegenerative Diseases |
| title_fullStr | Tau in Health and Neurodegenerative Diseases |
| title_full_unstemmed | Tau in Health and Neurodegenerative Diseases |
| title_short | Tau in Health and Neurodegenerative Diseases |
| title_sort | tau in health and neurodegenerative diseases |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/79430 |
| work_keys_str_mv | AT chudandan tauinhealthandneurodegenerativediseases AT liufei tauinhealthandneurodegenerativediseases |