Primary Intraocular Lymphoma: The Masquerade Syndrome

This chapter aims to provide a complete knowledge over the primary intraocular lymphoma (PIOL) and a correct clinical approach towards this rare condition, to avoid delays in diagnosis, which is considered the most important prognostic factor. A PIOL arises with no specific symptoms and could mimic...

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Autores principales: Lupi, Alessandro, Iaccheri, Barbara, Tucci, Davide, Cagini, Carlo, Fiore, Tito
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Lenguaje:inglés
Publicado: IntechOpen 2021
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Acceso en línea:https://www.intechopen.com/chapters/79713
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author Lupi, Alessandro
Iaccheri, Barbara
Tucci, Davide
Cagini, Carlo
Fiore, Tito
author_browse Cagini, Carlo
Fiore, Tito
Iaccheri, Barbara
Lupi, Alessandro
Tucci, Davide
author_facet Lupi, Alessandro
Iaccheri, Barbara
Tucci, Davide
Cagini, Carlo
Fiore, Tito
author_sort Lupi, Alessandro
building IntechOpen
collection Acceso abierto
description This chapter aims to provide a complete knowledge over the primary intraocular lymphoma (PIOL) and a correct clinical approach towards this rare condition, to avoid delays in diagnosis, which is considered the most important prognostic factor. A PIOL arises with no specific symptoms and could mimic both inflammatory and non-inflammatory ocular conditions. Also known as reticulum cell sarcoma in the past, PIOL is an ocular malignant condition, with a strong bond with primary central system lymphoma (PCNSL). This linkage is underlined by the fact that approximately 30% of the patients with PIOL have also PCNSL at presentation, while 45–90% will develop PCSNL in the following months. A correct diagnosis is currently achieved by the means of many different techniques: cytology, flow cytometry, immunohistochemistry, molecular analysis, and cytokines assay. Treatment of this condition has been completely revolutionized with the introduction of monoclonal antibodies directed against specific proteins present on the surface of lymphomatous cells.
doi_str_mv 10.5772/intechopen.101458
first_indexed 2026-10-15T21:39:22Z
format Book Chapter
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spelling intech-797132021-12-18 Primary Intraocular Lymphoma: The Masquerade Syndrome Alessandro Lupi Barbara Iaccheri Davide Tucci Carlo Cagini Tito Fiore Health Sciences This chapter aims to provide a complete knowledge over the primary intraocular lymphoma (PIOL) and a correct clinical approach towards this rare condition, to avoid delays in diagnosis, which is considered the most important prognostic factor. A PIOL arises with no specific symptoms and could mimic both inflammatory and non-inflammatory ocular conditions. Also known as reticulum cell sarcoma in the past, PIOL is an ocular malignant condition, with a strong bond with primary central system lymphoma (PCNSL). This linkage is underlined by the fact that approximately 30% of the patients with PIOL have also PCNSL at presentation, while 45–90% will develop PCSNL in the following months. A correct diagnosis is currently achieved by the means of many different techniques: cytology, flow cytometry, immunohistochemistry, molecular analysis, and cytokines assay. Treatment of this condition has been completely revolutionized with the introduction of monoclonal antibodies directed against specific proteins present on the surface of lymphomatous cells. IntechOpen 2021-12-18 Chapter, Part Of Book https://www.intechopen.com/chapters/79713 doi:10.5772/intechopen.101458 en ISBN:978-1-83968-111-0 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10790 ; Lymphoma
spellingShingle Health Sciences
Lupi, Alessandro
Iaccheri, Barbara
Tucci, Davide
Cagini, Carlo
Fiore, Tito
Primary Intraocular Lymphoma: The Masquerade Syndrome
title Primary Intraocular Lymphoma: The Masquerade Syndrome
title_full Primary Intraocular Lymphoma: The Masquerade Syndrome
title_fullStr Primary Intraocular Lymphoma: The Masquerade Syndrome
title_full_unstemmed Primary Intraocular Lymphoma: The Masquerade Syndrome
title_short Primary Intraocular Lymphoma: The Masquerade Syndrome
title_sort primary intraocular lymphoma the masquerade syndrome
topic Health Sciences
url https://www.intechopen.com/chapters/79713
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AT iaccheribarbara primaryintraocularlymphomathemasqueradesyndrome
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AT caginicarlo primaryintraocularlymphomathemasqueradesyndrome
AT fioretito primaryintraocularlymphomathemasqueradesyndrome