Molecular Informatics of Trypanothione Reductase of <em>Leishmania major</em> Reveals Novel Chromen-2-One Analogues as Potential Leishmanicides

Trypanothione reductase (TR), a flavoprotein oxidoreductase is an important therapeutic target for leishmaniasis. Ligand-based pharmacophore modelling and molecular docking were used to predict selective inhibitors against TR. Homology modelling was employed to generate a three-dimensional structure...

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Detalles Bibliográficos

Autores principales:	Kwofie, Samuel K., Kwarko, Gabriel B., Broni, Emmanuel, Adinortey, Michael B., Wilson, Michael D.
Formato:	Capítulo de libro
Lenguaje:	inglés
Publicado:	IntechOpen 2021
Materias:	Health Sciences
Acceso en línea:	https://www.intechopen.com/chapters/79718
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