Cytotoxicity and Antitumor Action of Lignans and Neolignans
Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activi...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2022
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| Acceso en línea: | https://www.intechopen.com/chapters/80708 |
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| author | Esquivel-Campos, Ana Laura Pérez-Gutiérrez, Salud Sánchez-Pérez, Leonor Campos-Xolalpa, Nimsi Pérez-Ramos, Julia |
| author_browse | Campos-Xolalpa, Nimsi Esquivel-Campos, Ana Laura Pérez-Gutiérrez, Salud Pérez-Ramos, Julia Sánchez-Pérez, Leonor |
| author_facet | Esquivel-Campos, Ana Laura Pérez-Gutiérrez, Salud Sánchez-Pérez, Leonor Campos-Xolalpa, Nimsi Pérez-Ramos, Julia |
| author_sort | Esquivel-Campos, Ana Laura |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activities, such as antioxidant, anti-inflammatory, antineurodegenerative, antiviral, antimicrobial, and antitumor. By 2040, it is estimated that the number of new cancer cases per year will rise to 29.5 million; therefore, the development of new anticancer agents and adjuvants is essential. Lignans and neolignans have also indicated a reduction in the risk of cancer at different stages. The objective of this review is to search and analyze the cytotoxic and antitumor activity of lignans and neolignans that can be an important source of new antitumor drugs. We have made a comprehensive summary of 113 lignans and neolignans, obtained from 44 plants and divided between 34 families, which demonstrated cytotoxic activity in several human cancer cell lines evaluated through various in vitro studies and other in vivo models, by inducing mitochondrial apoptosis and cell cycle arrest, inhibiting NF-κβ activity and activation of metalloproteinases (MMPs), among other processes. Overall, 13 compounds, methoxypinoresinol, arctigenin, trachelogenin, 4-O-methylhonokiol, honokiol, bifidenone, (−)-trachelogeninit, deoxypodophyllotoxin, matairesinol, bejolghotin G, H, and I, and hedyotol-B, showed the best anticancer activity. |
| doi_str_mv | 10.5772/intechopen.102223 |
| first_indexed | 2026-10-15T21:39:44Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-80708</identifier><datestamp>2022-03-04</datestamp>
<dc:title>Cytotoxicity and Antitumor Action of Lignans and Neolignans</dc:title>
<dc:creator>Ana Laura Esquivel-Campos</dc:creator>
<dc:creator>Salud Pérez-Gutiérrez</dc:creator>
<dc:creator>Leonor Sánchez-Pérez</dc:creator>
<dc:creator>Nimsi Campos-Xolalpa</dc:creator>
<dc:creator>Julia Pérez-Ramos</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description>Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activities, such as antioxidant, anti-inflammatory, antineurodegenerative, antiviral, antimicrobial, and antitumor. By 2040, it is estimated that the number of new cancer cases per year will rise to 29.5 million; therefore, the development of new anticancer agents and adjuvants is essential. Lignans and neolignans have also indicated a reduction in the risk of cancer at different stages. The objective of this review is to search and analyze the cytotoxic and antitumor activity of lignans and neolignans that can be an important source of new antitumor drugs. We have made a comprehensive summary of 113 lignans and neolignans, obtained from 44 plants and divided between 34 families, which demonstrated cytotoxic activity in several human cancer cell lines evaluated through various in vitro studies and other in vivo models, by inducing mitochondrial apoptosis and cell cycle arrest, inhibiting NF-κβ activity and activation of metalloproteinases (MMPs), among other processes. Overall, 13 compounds, methoxypinoresinol, arctigenin, trachelogenin, 4-O-methylhonokiol, honokiol, bifidenone, (−)-trachelogeninit, deoxypodophyllotoxin, matairesinol, bejolghotin G, H, and I, and hedyotol-B, showed the best anticancer activity.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2022-03-04</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/80708</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.102223</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-80355-207-1</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/11331 ; Secondary Metabolites - Trends and Reviews</dc:source>
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| id | intech-80708 |
| institution | IntechOpen |
| isbn | 978-1-80355-207-1 |
| language | English |
| last_indexed | 2026-10-15T21:39:44Z |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-807082022-03-04 Cytotoxicity and Antitumor Action of Lignans and Neolignans Ana Laura Esquivel-Campos Salud Pérez-Gutiérrez Leonor Sánchez-Pérez Nimsi Campos-Xolalpa Julia Pérez-Ramos Life Sciences Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activities, such as antioxidant, anti-inflammatory, antineurodegenerative, antiviral, antimicrobial, and antitumor. By 2040, it is estimated that the number of new cancer cases per year will rise to 29.5 million; therefore, the development of new anticancer agents and adjuvants is essential. Lignans and neolignans have also indicated a reduction in the risk of cancer at different stages. The objective of this review is to search and analyze the cytotoxic and antitumor activity of lignans and neolignans that can be an important source of new antitumor drugs. We have made a comprehensive summary of 113 lignans and neolignans, obtained from 44 plants and divided between 34 families, which demonstrated cytotoxic activity in several human cancer cell lines evaluated through various in vitro studies and other in vivo models, by inducing mitochondrial apoptosis and cell cycle arrest, inhibiting NF-κβ activity and activation of metalloproteinases (MMPs), among other processes. Overall, 13 compounds, methoxypinoresinol, arctigenin, trachelogenin, 4-O-methylhonokiol, honokiol, bifidenone, (−)-trachelogeninit, deoxypodophyllotoxin, matairesinol, bejolghotin G, H, and I, and hedyotol-B, showed the best anticancer activity. IntechOpen 2022-03-04 Chapter, Part Of Book https://www.intechopen.com/chapters/80708 doi:10.5772/intechopen.102223 en ISBN:978-1-80355-207-1 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/11331 ; Secondary Metabolites - Trends and Reviews |
| spellingShingle | Life Sciences Esquivel-Campos, Ana Laura Pérez-Gutiérrez, Salud Sánchez-Pérez, Leonor Campos-Xolalpa, Nimsi Pérez-Ramos, Julia Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title | Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title_full | Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title_fullStr | Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title_full_unstemmed | Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title_short | Cytotoxicity and Antitumor Action of Lignans and Neolignans |
| title_sort | cytotoxicity and antitumor action of lignans and neolignans |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/80708 |
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