Neuroimmunology and Neurological Manifestations of COVID-19

Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrus...

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Autor principal: Weissert, Robert
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Publicado: IntechOpen 2022
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Acceso en línea:https://www.intechopen.com/chapters/80821
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author Weissert, Robert
author_browse Weissert, Robert
author_facet Weissert, Robert
author_sort Weissert, Robert
building IntechOpen
collection Acceso abierto
description Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.
doi_str_mv 10.5772/intechopen.103026
first_indexed 2026-10-15T21:39:28Z
format Book Chapter
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spelling intech-808212022-03-17 Neuroimmunology and Neurological Manifestations of COVID-19 Robert Weissert Health Sciences Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study. IntechOpen 2022-03-17 Chapter, Part Of Book https://www.intechopen.com/chapters/80821 doi:10.5772/intechopen.103026 en ISBN:978-1-80355-030-5 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/10890 ; COVID-19, Neuroimmunology and Neural Function
spellingShingle Health Sciences
Weissert, Robert
Neuroimmunology and Neurological Manifestations of COVID-19
title Neuroimmunology and Neurological Manifestations of COVID-19
title_full Neuroimmunology and Neurological Manifestations of COVID-19
title_fullStr Neuroimmunology and Neurological Manifestations of COVID-19
title_full_unstemmed Neuroimmunology and Neurological Manifestations of COVID-19
title_short Neuroimmunology and Neurological Manifestations of COVID-19
title_sort neuroimmunology and neurological manifestations of covid 19
topic Health Sciences
url https://www.intechopen.com/chapters/80821
work_keys_str_mv AT weissertrobert neuroimmunologyandneurologicalmanifestationsofcovid19