The Potential of Precision Probiotic <em>Hafnia alvei</em> HA4597 to Support Weight Loss
Hafnia alvei HA4597® is a novel probiotic strain producing an anorexigenic mimetic protein. This report summarizes the innovative approach leading to the discovery of the precision probiotic H. alvei HA4597® and its benefits on body weight and metabolic parameters. H. alvei HA4597® has been identifi...
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| Autores principales: | , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/80869 |
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| Sumario: | Hafnia alvei HA4597® is a novel probiotic strain producing an anorexigenic mimetic protein. This report summarizes the innovative approach leading to the discovery of the precision probiotic H. alvei HA4597® and its benefits on body weight and metabolic parameters. H. alvei HA4597® has been identified after the striking findings on the effects of the bacterial metabolite ClpB (Caseinolytic peptidase B) on appetite regulation, through a screening of ClpB-producing strains. Its efficacy in humans has been validated by a multicentric, double-blind, randomized placebo-controlled trial including 236 overweight adults. The successful results on body weight loss of the clinical study support the use of H. alvei HA4597® in the global management of excess weight. |
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| ISBN: | 978-1-80355-186-9 |
| DOI: | 10.5772/intechopen.103723 |