Interaction of Ebola Virus with the Innate Immune System
<p id="p1">The Ebola viruses (EBOVs) are known as one the most lethal viruses. EBOV systemic infection can cause damage to vital organs and lead to death. The immune responses of the innate immune system and inflammatory cascade are critical elements in the EBOV pathogenesis and mortality. The prima...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/81667 |
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| Sumario: | <p id="p1">The Ebola viruses (EBOVs) are known as one the most lethal viruses. EBOV systemic infection can cause damage to vital organs and lead to death. The immune responses of the innate immune system and inflammatory cascade are critical elements in the EBOV pathogenesis and mortality. The primary innate immune system response can shape the adaptive immune responses. The innate immune response, due to the pattern-recognition receptors (PRRs), can induce interferons (IFN). IFN is a critical element in the antiviral response. The EBOV can evade the IFN and innate immunity using different mechanisms, whereas a well-controlled and sufficient innate immune response is vital for limiting the EBOV infection. In this regard, a hyperactive inflammation response may lead to cytokine storms and death. In this chapter, we have tried to provide a perspective on the pathogenesis and molecular mechanisms of the innate immune system and its interaction with EBOV infection.</p> |
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| ISBN: | 978-1-80355-624-6 |
| DOI: | 10.5772/intechopen.104843 |