The Role of IL-6 in RNA Virus Infection
IL-6 is a pleiotropic cytokine produced in response to tissue damage and infections. This up-regulation was observed during infection with a highly virulent VSV strain. There was potential association between IL-6 levels and virus virulence. In this chapter we would like to explore in more detail th...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/82086 |
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| Sumario: | IL-6 is a pleiotropic cytokine produced in response to tissue damage and infections. This up-regulation was observed during infection with a highly virulent VSV strain. There was potential association between IL-6 levels and virus virulence. In this chapter we would like to explore in more detail the biological functions of IL-6 in different virus models. We also discuss the debatable role of IL-6 during viral infections. Previous studies show the potential role of IL-6 to mount a proper immune response during some viral infections, others link this cytokine with exacerbation of viral disease. These latter findings lend support to the hypothesis that up-regulation of IL-6 during certain viral infections may promote virus survival and/or exacerbation of clinical disease. Previous experimental evidences also suggest potential negative consequences that increased levels of IL-6 might have on the cellular immune response against viruses. |
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| ISBN: | 978-1-80355-666-6 |
| DOI: | 10.5772/intechopen.104523 |