Noncanonical (Non-R132H) IDH-Mutated Gliomas
Mutations in IDH1 or IDH2 confer a significant survival advantage compared to their isocitrate dehydrogenase (IDH) wild-type counterparts and, as such, are the most significant prognostic factors in this group. The mutations in the IDH1 gene are heterozygous and almost always involve only a single r...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2022
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| Acceso en línea: | https://www.intechopen.com/chapters/82321 |
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| _version_ | 1879164789725331456 |
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| author | Al-Saadi, Tariq D. Diaz, Roberto J. |
| author_browse | Al-Saadi, Tariq D. Diaz, Roberto J. |
| author_facet | Al-Saadi, Tariq D. Diaz, Roberto J. |
| author_sort | Al-Saadi, Tariq D. |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Mutations in IDH1 or IDH2 confer a significant survival advantage compared to their isocitrate dehydrogenase (IDH) wild-type counterparts and, as such, are the most significant prognostic factors in this group. The mutations in the IDH1 gene are heterozygous and almost always involve only a single residue (arginine 132), which is replaced by histidine in roughly 90% of tumors. Regardless, the non-p.R132H (noncanonical) mutations in the IDH1 gene were also documented in around 20% of mutated glioma. The noncanonical IDH mutations have distinguishing radiological and histological features. The existence of such tumors seems to be associated with a genetic predisposition to cancer development. |
| doi_str_mv | 10.5772/intechopen.105469 |
| first_indexed | 2026-10-15T21:39:55Z |
| format | Book Chapter |
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<dc:title>Noncanonical (Non-R132H) IDH-Mutated Gliomas</dc:title>
<dc:creator>Tariq D. Al-Saadi</dc:creator>
<dc:creator>Roberto J. Diaz</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Mutations in IDH1 or IDH2 confer a significant survival advantage compared to their isocitrate dehydrogenase (IDH) wild-type counterparts and, as such, are the most significant prognostic factors in this group. The mutations in the IDH1 gene are heterozygous and almost always involve only a single residue (arginine 132), which is replaced by histidine in roughly 90% of tumors. Regardless, the non-p.R132H (noncanonical) mutations in the IDH1 gene were also documented in around 20% of mutated glioma. The noncanonical IDH mutations have distinguishing radiological and histological features. The existence of such tumors seems to be associated with a genetic predisposition to cancer development.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2022-07-02</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/82321</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.105469</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-80356-128-8</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/11597 ; Glioblastoma - Current Evidence</dc:source>
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| id | intech-82321 |
| institution | IntechOpen |
| isbn | 978-1-80356-128-8 |
| language | English |
| last_indexed | 2026-10-15T21:39:55Z |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-823212022-07-02 Noncanonical (Non-R132H) IDH-Mutated Gliomas Tariq D. Al-Saadi Roberto J. Diaz Health Sciences Mutations in IDH1 or IDH2 confer a significant survival advantage compared to their isocitrate dehydrogenase (IDH) wild-type counterparts and, as such, are the most significant prognostic factors in this group. The mutations in the IDH1 gene are heterozygous and almost always involve only a single residue (arginine 132), which is replaced by histidine in roughly 90% of tumors. Regardless, the non-p.R132H (noncanonical) mutations in the IDH1 gene were also documented in around 20% of mutated glioma. The noncanonical IDH mutations have distinguishing radiological and histological features. The existence of such tumors seems to be associated with a genetic predisposition to cancer development. IntechOpen 2022-07-02 Chapter, Part Of Book https://www.intechopen.com/chapters/82321 doi:10.5772/intechopen.105469 en ISBN:978-1-80356-128-8 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/11597 ; Glioblastoma - Current Evidence |
| spellingShingle | Health Sciences Al-Saadi, Tariq D. Diaz, Roberto J. Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title | Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title_full | Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title_fullStr | Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title_full_unstemmed | Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title_short | Noncanonical (Non-R132H) IDH-Mutated Gliomas |
| title_sort | noncanonical non r132h idh mutated gliomas |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/82321 |
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