Lupus Genetics
Lupus erythematosus is an autoimmune disorder with an important genetic component. Studies in monozygotic twins have revealed a concordance rate of 50% indicating that environmental factors might play a significant role in the development of the disease. Genes that are implicated in the pathogenesis...
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| Main Author: | |
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| Format: | Book Chapter |
| Language: | English |
| Published: |
IntechOpen
2022
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| Online Access: | https://www.intechopen.com/chapters/82979 |
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| Summary: | Lupus erythematosus is an autoimmune disorder with an important genetic component. Studies in monozygotic twins have revealed a concordance rate of 50% indicating that environmental factors might play a significant role in the development of the disease. Genes that are implicated in the pathogenesis of lupus erythematosus include HLA, Interferon genes, complement genes, cytokine genes (TNF, IL-10, IL-1β, IL-17, IL-23), NF-κB genes, ITGAM gene, PPP2CA genes, SIAE genes, SLAMF molecules, PTPN22, BLK, BANK1, PD-1 and X-linked genes (AIRE gene and others). Epigenetic factors which alter only the expression but not the DNA structure may also interfere with the development of the disease. |
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| ISBN: | 978-1-80356-347-3 |
| DOI: | 10.5772/intechopen.106372 |