Vitamin D Deficiency: Implications in COVID-19 and Schizophrenia
Deficiencies in vitamin D can have several etiologies, broadly classified as the following: suboptimal exposure to ultraviolet-B (UV-B) light from sunlight, low dietary intake of vitamin-D or reduced absorption due to gastrointestinal pathologies, reduced production due to liver or kidney disease, p...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2023
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/83102 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Deficiencies in vitamin D can have several etiologies, broadly classified as the following: suboptimal exposure to ultraviolet-B (UV-B) light from sunlight, low dietary intake of vitamin-D or reduced absorption due to gastrointestinal pathologies, reduced production due to liver or kidney disease, pseudo-deficiencies caused by end organ resistance despite normal or elevated vitamin D levels, and medication-induced stimulation of hepatic cytochrome P450 enzymes for which vitamin D is a substrate. Deficiencies in this important vitamin can have several adverse clinical implications such as osteomalacia, osteoporosis, muscle pain, and depression to name a few. More recently, vitamin D has been shown to be involved in modulating various aspects of the immune system. Vitamin D receptors have also been found to be present in certain regions of the brain, especially those involved in schizophrenia. We will discuss the implications of vitamin D deficiency and its immunomodulatory role in the setting of the COVID-19 virus, the proposed cellular and molecular mechanisms of action for vitamin D in the context of schizophrenia, and the clinical outcomes associated with these two pathologies as a function of low vitamin D levels. |
|---|---|
| ISBN: | 978-1-80356-515-6 |
| DOI: | 10.5772/intechopen.106801 |