Targeting Endoplasmic Reticulum and Mitochondrial Dynamics to Combat Triple-Negative Breast Cancer
Triple negative breast cancer (TNBC) is a cancer that is aggressive with short survival rate. In comparison to other breast cancer subtypes, TNBC tumors are bigger, more chemo resistant, highly proliferative, and usually more abundant in stem and immune cells. These modifications are functionally de...
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| Main Authors: | , |
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| Format: | Book Chapter |
| Language: | English |
| Published: |
IntechOpen
2022
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| Subjects: | |
| Online Access: | https://www.intechopen.com/chapters/83238 |
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| Summary: | Triple negative breast cancer (TNBC) is a cancer that is aggressive with short survival rate. In comparison to other breast cancer subtypes, TNBC tumors are bigger, more chemo resistant, highly proliferative, and usually more abundant in stem and immune cells. These modifications are functionally dependent on a high-quality endoplasmic reticulum and mitochondrial pool. Endoplasmic reticulum and mitochondrial health are monitored and enhanced on a regular basis via endoplasmic reticulum and mitochondrial dynamics. The role of endoplasmic reticulum and mitochondrial dynamics in tumor growth and metastasis has been highlighted by recent advances in understanding the endoplasmic reticulum and mitochondrial dynamics in TNBC. This chapter examines the current knowledge of endoplasmic reticulum and mitochondrial dynamics in TNBC. |
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| ISBN: | 978-1-80356-227-8 |
| DOI: | 10.5772/intechopen.106597 |