Astrocytic Abnormalities in Schizophrenia
Astrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2022
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| Acceso en línea: | https://www.intechopen.com/chapters/83421 |
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| _version_ | 1879164795538636800 |
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| author | Saleki, Kiarash Banazadeh, Mohammad Abadi, Banafshe Pirmoradi, Zeynab Esmaili, Zahra Amiri, Shiva Pourahmad, Ramtin Kohlmeier, Kristi A. Shabani, Mohammad |
| author_browse | Abadi, Banafshe Amiri, Shiva Banazadeh, Mohammad Esmaili, Zahra Kohlmeier, Kristi A. Pirmoradi, Zeynab Pourahmad, Ramtin Saleki, Kiarash Shabani, Mohammad |
| author_facet | Saleki, Kiarash Banazadeh, Mohammad Abadi, Banafshe Pirmoradi, Zeynab Esmaili, Zahra Amiri, Shiva Pourahmad, Ramtin Kohlmeier, Kristi A. Shabani, Mohammad |
| author_sort | Saleki, Kiarash |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Astrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric disorder associated with various positive and negative behaviors and interruption of executive function and cognition thought to be due partly to aberrations in signaling within neural networks. Recent research has demonstrated that astrocytes play a role in SCZ through various effects, including influencing immune system function, altering white matter, and mediating changes in neurotransmitters. Astrocytes are also known to play a role in inducing SCZ-associated changes in neuroplasticity, which includes alterations in synaptic strength and neurogenesis. Also, astrocyte abnormalities are linked to neurobehavioral impairments seen at the clinical level. The present chapter details general information on SCZ. It highlights the role of astrocytes in SCZ at molecular and behavioral levels, including neural changes seen in the disease, and the therapeutic implications of targeting astrocytes in SCZ. |
| doi_str_mv | 10.5772/intechopen.106618 |
| first_indexed | 2026-10-15T21:40:01Z |
| format | Book Chapter |
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<dc:title>Astrocytic Abnormalities in Schizophrenia</dc:title>
<dc:creator>Kiarash Saleki</dc:creator>
<dc:creator>Mohammad Banazadeh</dc:creator>
<dc:creator>Banafshe Abadi</dc:creator>
<dc:creator>Zeynab Pirmoradi</dc:creator>
<dc:creator>Zahra Esmaili</dc:creator>
<dc:creator>Shiva Amiri</dc:creator>
<dc:creator>Ramtin Pourahmad</dc:creator>
<dc:creator>Kristi A. Kohlmeier</dc:creator>
<dc:creator>Mohammad Shabani</dc:creator>
<dc:subject>Life Sciences</dc:subject>
<dc:description>Astrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric disorder associated with various positive and negative behaviors and interruption of executive function and cognition thought to be due partly to aberrations in signaling within neural networks. Recent research has demonstrated that astrocytes play a role in SCZ through various effects, including influencing immune system function, altering white matter, and mediating changes in neurotransmitters. Astrocytes are also known to play a role in inducing SCZ-associated changes in neuroplasticity, which includes alterations in synaptic strength and neurogenesis. Also, astrocyte abnormalities are linked to neurobehavioral impairments seen at the clinical level. The present chapter details general information on SCZ. It highlights the role of astrocytes in SCZ at molecular and behavioral levels, including neural changes seen in the disease, and the therapeutic implications of targeting astrocytes in SCZ.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2022-09-03</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/83421</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.106618</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-80356-068-7</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/11742 ; Neurophysiology - Networks, Plasticity, Pathophysiology and Behavior</dc:source>
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| id | intech-83421 |
| institution | IntechOpen |
| isbn | 978-1-80356-068-7 |
| language | English |
| last_indexed | 2026-10-15T21:40:01Z |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-834212022-09-03 Astrocytic Abnormalities in Schizophrenia Kiarash Saleki Mohammad Banazadeh Banafshe Abadi Zeynab Pirmoradi Zahra Esmaili Shiva Amiri Ramtin Pourahmad Kristi A. Kohlmeier Mohammad Shabani Life Sciences Astrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric disorder associated with various positive and negative behaviors and interruption of executive function and cognition thought to be due partly to aberrations in signaling within neural networks. Recent research has demonstrated that astrocytes play a role in SCZ through various effects, including influencing immune system function, altering white matter, and mediating changes in neurotransmitters. Astrocytes are also known to play a role in inducing SCZ-associated changes in neuroplasticity, which includes alterations in synaptic strength and neurogenesis. Also, astrocyte abnormalities are linked to neurobehavioral impairments seen at the clinical level. The present chapter details general information on SCZ. It highlights the role of astrocytes in SCZ at molecular and behavioral levels, including neural changes seen in the disease, and the therapeutic implications of targeting astrocytes in SCZ. IntechOpen 2022-09-03 Chapter, Part Of Book https://www.intechopen.com/chapters/83421 doi:10.5772/intechopen.106618 en ISBN:978-1-80356-068-7 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/11742 ; Neurophysiology - Networks, Plasticity, Pathophysiology and Behavior |
| spellingShingle | Life Sciences Saleki, Kiarash Banazadeh, Mohammad Abadi, Banafshe Pirmoradi, Zeynab Esmaili, Zahra Amiri, Shiva Pourahmad, Ramtin Kohlmeier, Kristi A. Shabani, Mohammad Astrocytic Abnormalities in Schizophrenia |
| title | Astrocytic Abnormalities in Schizophrenia |
| title_full | Astrocytic Abnormalities in Schizophrenia |
| title_fullStr | Astrocytic Abnormalities in Schizophrenia |
| title_full_unstemmed | Astrocytic Abnormalities in Schizophrenia |
| title_short | Astrocytic Abnormalities in Schizophrenia |
| title_sort | astrocytic abnormalities in schizophrenia |
| topic | Life Sciences |
| url | https://www.intechopen.com/chapters/83421 |
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