Recombinant Interferon Gamma: Influence on the Cytotoxic Activity of NK Cells in Patients with Chronic Epstein-Barr Virus Infection
NK cells play an important role in combating viral infections. In this study, we examined the effect of therapy with recombinant interferon gamma (Ingaron) on cytotoxic activity of NK cells. Sixty patients with chronic Epstein-Barr virus infection (CEBVI) were examined. All patients were treated wit...
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| Autores principales: | , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/84378 |
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| Sumario: | NK cells play an important role in combating viral infections. In this study, we examined the effect of therapy with recombinant interferon gamma (Ingaron) on cytotoxic activity of NK cells. Sixty patients with chronic Epstein-Barr virus infection (CEBVI) were examined. All patients were treated with Ingaron at a dose of 500,000 IU every other day IM. Initially, they received 10 injections of Ingaron followed by a 10-day break to assess the dynamics of clinical and laboratory parameters. Then, the treatment was continued with five injections of Ingaron. In total, each patient received 15 injections or a total dose of 7,500,000 IU. The administration of recombinant interferon gamma at a total dose of 5,000,000 IU stimulated spontaneous and induced degranulation of NK cells in patients with CEBVI. After a full course of 7,500,000 IU of recombinant interferon gamma, CD107a expression on NK cells decreased but remained higher than before the onset of therapy and exceeded reference values. Thus, the maximum activity of NK cells in the peripheral blood of patients with CEBVI was reached 10 days after the administration of Ingaron at a total dose of 5,000,000 IU. |
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| ISBN: | 978-1-83768-943-9 |
| DOI: | 10.5772/intechopen.108207 |