Trans-Resveratrol: From Phytonutrient Supplement, to Novel Nanotherapeutic Agent
<p id="p1">Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) (RES) is a plant polyphenol that has been well documented for its anti-oxidant, antimicrobial, anti-inflammatory, and anti-aging properties. Moreover, compelling evidence presented in the abundance of pre-clinical studies using li...
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| Autor principal: | |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/84692 |
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| Sumario: | <p id="p1">Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) (RES) is a plant polyphenol that has been well documented for its anti-oxidant, antimicrobial, anti-inflammatory, and anti-aging properties. Moreover, compelling evidence presented in the abundance of pre-clinical studies using ligature-induced periodontitis models has positioned RES as a theoretically viable candidate for the reduction of the chronic inflammation, oxidative stress, and tissue destruction seen in periodontitis (PD). However, the instability of RES under physiological conditions, as well as its rapid hepatic clearance, has presented as a challenge to its ubiquitous application as an oral therapeutic in clinical practice. Fortunately, with the application of nanotechnology, the pharmacological profile of RES repositions the phytochemical from an herb-based supplement, useful as an adjunct therapy, to a stable and potent nanomedicine, demonstrating efficacy for the prevention and treatment of PD and its associated systemic diseases. This chapter explores the details of the potential for nano-RES as a viable therapeutic for PD.</p> |
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| ISBN: | 978-1-80356-992-5 |
| DOI: | 10.5772/intechopen.108496 |