Discovery of BRCA Mutations: Historical Perspective of Its Scientific, Clinical and Social Impact

In the human genome, BRCA1 and BRCA2 (for BReast CAncer 1 and 2) genes encode for proteins involved in several functions that are crucial for the maintenance of genome stability and integrity. They participate in DNA damage response and repair pathways and, therefore, act as tumor suppressor genes....

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Autores principales: Burachik, Natalia B., Ortiz, Ana Laura, Kordon, Edith C.
Formato: Capítulo de libro
Lenguaje:inglés
Publicado: IntechOpen 2023
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Acceso en línea:https://www.intechopen.com/chapters/84767
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