Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment
Liver cancer represents one of the most common solid tumors globally. Despite curative improvements made in liver cancer therapy these years, the 5-year survival rate of liver cancer remains poor. Understanding the mechanisms involved in the initiation and progression of liver cancer is essential fo...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/84792 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1879164789720088576 |
|---|---|
| author | Jin, Cheng Liu, You-Yi Wang, Bo-Shi |
| author_browse | Jin, Cheng Liu, You-Yi Wang, Bo-Shi |
| author_facet | Jin, Cheng Liu, You-Yi Wang, Bo-Shi |
| author_sort | Jin, Cheng |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Liver cancer represents one of the most common solid tumors globally. Despite curative improvements made in liver cancer therapy these years, the 5-year survival rate of liver cancer remains poor. Understanding the mechanisms involved in the initiation and progression of liver cancer is essential for optimizing therapeutic strategies. In recent years, it has been discovered that the acidic tumor microenvironment attributed to increased glycolysis, and hypoxia contributes to liver cancer progression through promoting cancer cell proliferation, metabolic adaptation, and migration and invasion. In this paper, research advances in the mechanisms of hepatocarcinogenesis development under an acidic microenvironment are reviewed. |
| doi_str_mv | 10.5772/intechopen.108559 |
| first_indexed | 2026-10-15T21:39:55Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-84792</identifier><datestamp>2022-11-13</datestamp>
<dc:title>Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment</dc:title>
<dc:creator>Cheng Jin</dc:creator>
<dc:creator>You-Yi Liu</dc:creator>
<dc:creator>Bo-Shi Wang</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Liver cancer represents one of the most common solid tumors globally. Despite curative improvements made in liver cancer therapy these years, the 5-year survival rate of liver cancer remains poor. Understanding the mechanisms involved in the initiation and progression of liver cancer is essential for optimizing therapeutic strategies. In recent years, it has been discovered that the acidic tumor microenvironment attributed to increased glycolysis, and hypoxia contributes to liver cancer progression through promoting cancer cell proliferation, metabolic adaptation, and migration and invasion. In this paper, research advances in the mechanisms of hepatocarcinogenesis development under an acidic microenvironment are reviewed.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2022-11-13</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/84792</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.108559</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-80356-413-5</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/11596 ; Liver Cancer - Genesis, Progression and Metastasis</dc:source>
</oai_dc:dc> |
| id | intech-84792 |
| institution | IntechOpen |
| isbn | 978-1-80356-413-5 |
| language | English |
| last_indexed | 2026-10-15T21:39:55Z |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-847922022-11-13 Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment Cheng Jin You-Yi Liu Bo-Shi Wang Health Sciences Liver cancer represents one of the most common solid tumors globally. Despite curative improvements made in liver cancer therapy these years, the 5-year survival rate of liver cancer remains poor. Understanding the mechanisms involved in the initiation and progression of liver cancer is essential for optimizing therapeutic strategies. In recent years, it has been discovered that the acidic tumor microenvironment attributed to increased glycolysis, and hypoxia contributes to liver cancer progression through promoting cancer cell proliferation, metabolic adaptation, and migration and invasion. In this paper, research advances in the mechanisms of hepatocarcinogenesis development under an acidic microenvironment are reviewed. IntechOpen 2022-11-13 Chapter, Part Of Book https://www.intechopen.com/chapters/84792 doi:10.5772/intechopen.108559 en ISBN:978-1-80356-413-5 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/11596 ; Liver Cancer - Genesis, Progression and Metastasis |
| spellingShingle | Health Sciences Jin, Cheng Liu, You-Yi Wang, Bo-Shi Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title | Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title_full | Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title_fullStr | Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title_full_unstemmed | Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title_short | Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment |
| title_sort | mechanisms of hepatocarcinogenesis development in an acidic microenvironment |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/84792 |
| work_keys_str_mv | AT jincheng mechanismsofhepatocarcinogenesisdevelopmentinanacidicmicroenvironment AT liuyouyi mechanismsofhepatocarcinogenesisdevelopmentinanacidicmicroenvironment AT wangboshi mechanismsofhepatocarcinogenesisdevelopmentinanacidicmicroenvironment |