Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs
Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liq...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2022
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| Acceso en línea: | https://www.intechopen.com/chapters/84821 |
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| _version_ | 1879164812468944896 |
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| author | Kasturi, Madhavi |
| author_browse | Kasturi, Madhavi |
| author_facet | Kasturi, Madhavi |
| author_sort | Kasturi, Madhavi |
| building | IntechOpen |
| collection | Acceso abierto |
| description | Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre- and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs. |
| doi_str_mv | 10.5772/intechopen.108706 |
| first_indexed | 2026-10-15T21:40:17Z |
| format | Book Chapter |
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<dc:title>Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs</dc:title>
<dc:creator>Madhavi Kasturi</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description>Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre- and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs.</dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2022-11-15</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/84821</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.108706</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-1-83768-471-7</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/12326 ; Drug Formulation Design</dc:source>
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| id | intech-84821 |
| institution | IntechOpen |
| isbn | 978-1-83768-471-7 |
| language | English |
| last_indexed | 2026-10-15T21:40:17Z |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-848212022-11-15 Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs Madhavi Kasturi Health Sciences Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre- and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs. IntechOpen 2022-11-15 Chapter, Part Of Book https://www.intechopen.com/chapters/84821 doi:10.5772/intechopen.108706 en ISBN:978-1-83768-471-7 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/12326 ; Drug Formulation Design |
| spellingShingle | Health Sciences Kasturi, Madhavi Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title | Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title_full | Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title_fullStr | Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title_full_unstemmed | Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title_short | Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs |
| title_sort | development of liquisolid compacts an approach for dissolution enhancement of poorly aqueous soluble drugs |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/84821 |
| work_keys_str_mv | AT kasturimadhavi developmentofliquisolidcompactsanapproachfordissolutionenhancementofpoorlyaqueoussolubledrugs |